Department of Pathology, Immunology, and Laboratory Medicine , University of Florida, College of Medicine , Gainesville , Florida 32608 , United States.
Southeast Center for Integrated Metabolomics (SECIM), Clinical and Translational Science Institute , University of Florida , Gainesville , Florida 32608 , United States.
Anal Chem. 2019 Dec 3;91(23):14784-14791. doi: 10.1021/acs.analchem.9b03338. Epub 2019 Nov 14.
Child malnutrition (CM) is a global public health problem. It contributes to poor health in one in four children under five years worldwide and causes serious health problems in children, including stunted, wasted, and overweight growth. These serious public health issues lead to a higher chance of living in poverty in adulthood. Malnutrition is related with reduced economic productivity and increases the serious national and international burden. Currently, there is no meaningful therapeutic intervention of CM, and the use of different therapeutic foods has shown poor outcomes among supplemented malnourished children. The role of metabolites and lipids has been extensively recognized as early determinants of child health, but their contribution in CM and its pathobiology are poorly understood. This perspective provides a most recent update on these aspects. After briefly introducing the disciplines of metabolomics and lipidomics, we describe a mass spectrometry-based metabolic workflow for analysis of both metabolites and lipids and summarize several recent applications of metabolomics and lipidomics in CM. Finally, we discuss the future directions of the field toward the development of meaningful interventions for CM through metabolomics and lipidomics advances.
儿童营养不良（CM）是一个全球性的公共卫生问题。它导致全世界每四个五岁以下儿童中就有一人健康状况不佳，并导致儿童出现严重的健康问题，包括发育迟缓、消瘦和超重。这些严重的公共卫生问题导致他们在成年后更有可能陷入贫困。营养不良与经济生产力下降有关，并增加了严重的国家和国际负担。目前，CM 没有有意义的治疗干预措施，并且不同治疗食品的使用在补充营养不良儿童中显示出较差的结果。代谢物和脂质的作用已被广泛认为是儿童健康的早期决定因素，但它们在 CM 及其病理生物学中的作用还知之甚少。本观点提供了这些方面的最新更新。在简要介绍代谢组学和脂质组学的学科之后，我们描述了一种基于质谱的代谢物和脂质分析代谢工作流程，并总结了代谢组学和脂质组学在 CM 中的几个最新应用。最后，我们讨论了该领域的未来方向，即通过代谢组学和脂质组学的进展，为 CM 开发有意义的干预措施。
