Kollmann Martina, Obermayer-Pietsch Barbara, Lerchbaum Elisabeth, Lang Uwe, Herzog Sereina A, Trummer Christian, Scheuchenegger Anna, Ulrich Daniela, Klaritsch Philipp
Division of Obstetrics and Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Medical University of Graz, 8036 Graz, Austria.
Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, 8036 Graz, Austria.
J Clin Med. 2019 Nov 1;8(11):1817. doi: 10.3390/jcm8111817.
The aetiology of polycystic ovary syndrome (PCOS) is not particularly mapped; however, a complex interaction of various factors, such as genetic, environmental and intrauterine factors, can be assumed. Experimental animal studies and clinical observations support the hypothesis that developmental programming by excess intrauterine steroid is relevant. The aim of the study was to investigate whether mothers with and without PCOS exhibit different androgen and anti-Mullerian hormone (AMH) levels at the end of pregnancy and how maternal hormone levels are reflected in their offspring. Between March 2013 and December 2015, we performed a prospective cross-sectional study at the Medical University of Graz. We included 79 women with PCOS according to the ESHRE/ASRM 2003 definition and 354 women without PCOS, both with an ongoing pregnancy ≥37 + 0 weeks of gestation, who gave birth in our institution. Primary outcome parameters were the levels of maternal and neonatal androgens (testosterone, free testosterone, androstenedione) and AMH at delivery. Androgen levels in female offspring of PCOS and non-PCOS women at birth did not differ, while maternal hormone levels differed significantly. Androgen levels in PCOS boys were significantly higher when compared to levels in PCOS girls. Our findings do not support the hypothesis that maternal androgen excess contributes to elevated androgen concentrations in the female offspring. Nevertheless, the effects of the increased androgen concentrations in mothers on their offspring have to be investigated in future studies.
多囊卵巢综合征（PCOS）的病因尚未完全明确；然而，可以推测其是由多种因素（如遗传、环境和宫内因素）复杂相互作用所致。实验动物研究和临床观察支持了宫内类固醇过量导致发育编程异常这一假说。本研究的目的是调查患有和未患有PCOS的母亲在妊娠末期雄激素和抗苗勒管激素（AMH）水平是否存在差异，以及母体激素水平如何在其后代中体现。2013年3月至2015年12月，我们在格拉茨医科大学进行了一项前瞻性横断面研究。我们纳入了79例符合2003年ESHRE/ASRM定义的PCOS女性和354例无PCOS的女性，她们均为妊娠≥37 + 0周且在我们机构分娩的孕妇。主要结局参数为分娩时母体和新生儿雄激素（睾酮、游离睾酮、雄烯二酮）和AMH水平。PCOS女性和非PCOS女性的雌性后代出生时雄激素水平无差异，而母体激素水平差异显著。与PCOS女孩相比，PCOS男孩的雄激素水平显著更高。我们的研究结果不支持母体雄激素过量导致雌性后代雄激素浓度升高这一假说。尽管如此，母亲雄激素浓度升高对其后代的影响仍有待未来研究进一步探讨。
