Medical Biochemistry Department, National Research Centre, Dokki, Giza 12622, Egypt.
Stem Cells and Cell Therapy Laboratory, Biocruces Bizkaia Health Research Institute, Cruces University Hospital, Plaza de Cruces S/N, 48903 Barakaldo, Bizkaia, Spain.
Int J Mol Sci. 2019 Nov 2;20(21):5467. doi: 10.3390/ijms20215467.
Mesenchymal stem cells (MSCs) are capable of differentiating into multilineage cells, thus making them a significant prospect as a cell source for regenerative therapy; however, the differentiation capacity of MSCs into osteoblasts seems to not be the main mechanism responsible for the benefits associated with human mesenchymal stem cells hMSCs when used in cell therapy approaches. The process of bone fracture restoration starts with an instant inflammatory reaction, as the innate immune system responds with cytokines that enhance and activate many cell types, including MSCs, at the site of the injury. In this review, we address the influence of MSCs on the immune system in fracture repair and osteogenesis. This paradigm offers a means of distinguishing target bone diseases to be treated with MSC therapy to enhance bone repair by targeting the crosstalk between MSCs and the immune system.
间充质干细胞（MSCs）能够分化为多能细胞，因此成为再生治疗的重要细胞来源；然而，MSCs 向成骨细胞的分化能力似乎不是人骨髓间充质干细胞（hMSCs）在细胞治疗方法中发挥作用时与益处相关的主要机制。骨折修复过程始于即时炎症反应，因为先天免疫系统通过细胞因子作出反应，增强和激活许多细胞类型，包括损伤部位的 MSCs。在这篇综述中，我们探讨了 MSCs 在骨折修复和骨生成中对免疫系统的影响。这一范例提供了一种区分以 MSC 治疗为目标的骨骼疾病的方法，通过靶向 MSCs 与免疫系统之间的串扰来增强骨骼修复。
