Steineck Angela, Bradford Miranda C, Lau Nancy, Scott Samantha, Yi-Frazier Joyce P, Rosenberg Abby R
Center for Cancer and Blood Disorders Center, Seattle Children's Hospital, Seattle, WA 98105, USA.
Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98105, USA.
Children (Basel). 2019 Nov 2;6(11):124. doi: 10.3390/children6110124.
Promoting Resilience in Stress Management (PRISM), a psychosocial intervention for adolescents and young adults (AYAs) with serious illness, enhances resilience resources via four skills-based training sessions. A recent randomized controlled trial showed PRISM improved health-related quality of life (HRQOL) compared to usual care (UC). This post hoc exploratory analysis aimed to better understand the effect of PRISM on HRQOL by describing changes in HRQOL subdomain scores. English-speaking AYAs (12-25 years) with cancer were randomized to PRISM or UC. At enrollment and six months later, HRQOL was assessed using the Pediatric Quality of Life Inventory (PedsQL) Generic Short Form (SF-15) and Cancer Module. Scores at each time point were summarized descriptively and individual HRQOL trajectories were categorized (<70 vs. ≥70). "Positive" trajectories indicate participants maintained scores ≥70 or improved from <70 to ≥70 during the study period. Baseline assessments were completed by 92 participants (48 PRISM, 44 UC); six-month assessments were completed by 74 participants (36 PRISM, 38 UC). For the SF-15, positive trajectories in psychosocial domains were more common with PRISM; trajectories in the physical subdomain were similar across groups. For the Cancer Module, positive trajectories were more common with PRISM in the following subdomains: nausea, treatment anxiety, worry, cognitive, physical appearance, and communication. From this, we conclude PRISM may improve HRQOL, especially in psychosocial domains of wellbeing.
促进压力管理中的复原力（PRISM）是一项针对患有严重疾病的青少年和青年（AYAs）的社会心理干预措施，通过四次基于技能的培训课程增强复原力资源。最近一项随机对照试验表明，与常规护理（UC）相比，PRISM改善了健康相关生活质量（HRQOL）。这项事后探索性分析旨在通过描述HRQOL子领域得分的变化，更好地了解PRISM对HRQOL的影响。将患有癌症的英语为母语的AYAs（12 - 25岁）随机分为PRISM组或UC组。在入组时和六个月后，使用儿童生活质量量表（PedsQL）通用简表（SF - 15）和癌症模块评估HRQOL。对每个时间点的得分进行描述性总结，并将个体HRQOL轨迹分类（<70 vs.≥70）。“积极”轨迹表明参与者在研究期间保持得分≥70或从<70提高到≥70。92名参与者（48名PRISM组，44名UC组）完成了基线评估；74名参与者（36名PRISM组，38名UC组）完成了六个月评估。对于SF - 15，PRISM组在心理社会领域的积极轨迹更为常见；身体子领域的轨迹在各组之间相似。对于癌症模块，PRISM组在以下子领域的积极轨迹更为常见：恶心、治疗焦虑、担忧、认知、外貌和沟通。据此，我们得出结论，PRISM可能改善HRQOL，尤其是在幸福的心理社会领域。
