宫内节育器铜对宫颈黏液卵磷脂脂肪酸组成的影响。

The influence of copper intrauterine device on fatty acid composition of cervical mucus lecithin.

作者信息

Pschera H, Larsson B, Lindhe B A, Kjaeldgaard A

机构信息

Department of Obstetrics and Gynecology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.

出版信息

Contraception. 1988 Sep;38(3):341-8. doi: 10.1016/0010-7824(88)90106-0.

DOI:10.1016/0010-7824(88)90106-0

PMID:3168451

Abstract

Fatty acid composition of lecithin was analysed in midcycle cervical mucus obtained from 19 women using a copper intrauterine device (Cu-IUD) and 16 controls. In both groups, palmitic (16:0) acid was the predominant fatty acid and oleic (18:1) acid the second largest component. In women using a Cu-IUD, levels of myristic (14:0) acid were significantly lower, while levels of linoleic (18:2) and docosahexaenoic (22:6) acid were significantly higher than in controls. These changes in fatty acid composition could not be related to duration of IUD use and were very similar to those observed in women with primary unexplained infertility, suggesting that the Cu-IUD-induced modification of fatty acid pattern in midcycle mucus lecithin may be part of the contraceptive mechanism of action.

摘要

对19名使用铜宫内节育器（Cu-IUD）的女性和16名对照者在月经周期中期获取的宫颈黏液中的卵磷脂脂肪酸组成进行了分析。在两组中，棕榈酸（16:0）是主要脂肪酸，油酸（18:1）是第二大成分。使用Cu-IUD的女性中，肉豆蔻酸（14:0）水平显著较低，而亚油酸（18:2）和二十二碳六烯酸（22:6）水平显著高于对照者。脂肪酸组成的这些变化与宫内节育器使用时长无关，且与原发性不明原因不孕症女性中观察到的变化非常相似，这表明Cu-IUD引起的月经周期中期黏液卵磷脂脂肪酸模式改变可能是避孕作用机制的一部分。