Langer K, Fröhling P T, Diederich J, Brandl M, Lindenau K, Fekl W
Research Institute for Experimental Nutrition, Erlangen, FRG.
Contrib Nephrol. 1988;65:55-9. doi: 10.1159/000415748.
During both early and late stages of chronic renal insufficiency the response of BCKA to the disease state, as indicated by plasma levels, differs from that of BCAA. Val is the only BCAA whose concentration changes under the conditions of our study, and this only during the more advanced stages of disease. In contrast, all three BCKA declined, KIVA and KICA even in mild renal failure, showing that already during the early stages of the disease these BCKA levels are decreased. BCKA are more sensitive parameters than the corresponding amino acids with regard to the metabolic dysfunctions characteristic of this disease. Modern analytical methods allow more exact and reliable knowledge of these indicators and thus a better understanding of biochemical mechanisms, possibly resulting in better therapy.
在慢性肾功能不全的早期和晚期，支链α-酮酸（BCKA）对疾病状态的反应（以血浆水平表示）与支链氨基酸（BCAA）不同。缬氨酸（Val）是在我们的研究条件下其浓度发生变化的唯一一种BCAA，而且仅在疾病的更晚期阶段才发生变化。相比之下，所有三种BCKA均下降，即使在轻度肾衰竭时，α-酮异己酸（KIVA）和α-酮异戊酸（KICA）也下降，这表明在疾病的早期阶段这些BCKA水平就已降低。就该疾病的代谢功能障碍特征而言，BCKA是比相应氨基酸更敏感的参数。现代分析方法使人们能够更准确、可靠地了解这些指标，从而更好地理解生化机制，可能带来更好的治疗效果。
