Institute of Physiotherapy, OsloMet - Oslo Metropolitan University, PO Box 4, St. Olavs Plass, 0130, Oslo, Norway.
Leader of the Institute of Physiotherapy, OsloMet - Oslo Metropolitan University, Oslo, Norway.
BMC Geriatr. 2019 Nov 4;19(1):298. doi: 10.1186/s12877-019-1268-y.
Osteoporosis and vertebral fractures represent a major health burden worldwide, and the prevalence of osteoporosis is expected to increase as the world's population ages. Suffering from vertebral fracture has a substantial impact on the individual's health-related quality of life (HRQoL), physical function and pain. Complex health challenges experienced by older people with osteoporosis and vertebral fractures call for identification of factors that may influence HRQoL, as some of these factors may be modifiable. The objective is to examine the independent associations between HRQoL, physical function and pain in older women with osteoporosis and vertebral fracture.
This study has a cross-sectional design, using data from 149 home-dwelling Norwegian women with osteoporosis and vertebral fracture, aged 65+. Data on HRQoL (Short Form 36 (SF-36), Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO-41)), physical function (walking speed, balance and strength), pain, as well as sociodemographic information were collected. Simple linear regression analyses were conducted and multivariable regression models were fitted to investigate the associations.
Lower levels of HRQoL were significantly associated with lower levels of physical function, measured by walking speed, and higher levels of pain. Pain was significantly associated with all of the subscales in SF-36, with the exception of Mental Health and Mental Component Score, and all the subscales of QUALEFFO-41. Walking speed was significantly associated with 5 of 8 subscales of SF-36 (except Bodily Pain, Vitality, Mental Health and Mental Component Score), and with 4 of 6 subscales of QUALEFFO-41 (except Score Pain and Mood).
This study shows that pain and walking speed were, independently of one another, associated with HRQoL in older women with osteoporosis and vertebral fracture. These findings can inform clinicians and health managers about the importance of pain management and exercise interventions in health care for this group. Future research should address interventions targeting both physical function and pain with HRQoL as an outcome.
ClincialTrials.gov Identifier: NCT02781974. Registered 18.05.16. Retrospectively registered.
骨质疏松症和椎体骨折是全球范围内的重大健康负担，随着世界人口老龄化，骨质疏松症的患病率预计将增加。椎体骨折会对个体的健康相关生活质量（HRQoL）、身体功能和疼痛产生重大影响。患有骨质疏松症和椎体骨折的老年人面临着复杂的健康挑战，需要确定可能影响 HRQoL 的因素，因为其中一些因素可能是可以改变的。本研究旨在探讨老年女性骨质疏松症和椎体骨折患者 HRQoL、身体功能和疼痛之间的独立相关性。
本研究采用横断面设计，使用了 149 名居住在挪威的 65 岁以上骨质疏松症和椎体骨折的女性患者的数据。收集了 HRQoL（SF-36 简短量表，欧洲骨质疏松基金会生活质量问卷（QUALEFFO-41））、身体功能（行走速度、平衡和力量）、疼痛以及社会人口统计学信息。进行了简单线性回归分析，并拟合了多变量回归模型以探讨相关性。
HRQoL 水平较低与行走速度较低和疼痛程度较高显著相关。疼痛与 SF-36 的所有子量表（除了心理健康和心理成分评分）和 QUALEFFO-41 的所有子量表显著相关。行走速度与 SF-36 的 8 个子量表中的 5 个子量表（除了身体疼痛、活力、心理健康和心理成分评分）和 QUALEFFO-41 的 6 个子量表中的 4 个子量表（除了疼痛评分和情绪）显著相关。
本研究表明，疼痛和行走速度独立于彼此，与患有骨质疏松症和椎体骨折的老年女性的 HRQoL 相关。这些发现可以为临床医生和卫生管理人员提供信息，了解疼痛管理和锻炼干预在该人群医疗保健中的重要性。未来的研究应该针对以 HRQoL 为结果的身体功能和疼痛的干预措施。
ClincialTrials.gov 标识符：NCT02781974。于 2016 年 5 月 18 日注册。回顾性注册。
