Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
BMC Geriatr. 2024 Sep 17;24(1):766. doi: 10.1186/s12877-024-05348-9.
BACKGROUND & OBJECTIVE: Osteoporosis is a growing public health concern, particularly among the aging population. This study aimed to evaluate the association between osteoporosis and quality of life (QoL) in a sample of older adults.
This cross-sectional study utilized data from all the participants of Bushehr Elderly Health program (BEHP), phase 2. QoL was assessed using the 12-Item Short Form Survey (SF-12 Questionnaire), and participants were classified as having osteoporosis or not based on the WHO diagnostic criteria. The physical (PCS) and mental (MCS) component summaries of QoL were estimated. The association between osteoporosis and QoL was evaluated separately for men and women, considering various health and lifestyle factors using linear regression analysis.
The study included 2,399 participants (average age 71.27 ± 7.36 years). 1,246 were women and 1,153 were men. Osteoporosis was present in 59% of women and 23% of men. Participants with osteoporosis had significantly lower PCS scores compared to those without osteoporosis (women: 38.1 vs. 40.2, p < 0.001; men: 44.3 vs. 45.8, p: 0.002). However, there was no statistically significant difference in MCS scores. Stratified by sex, osteoporosis was significantly associated with PCS in women [β = -2.14 (-3.13, -1.15)] and men [β = -1.53 (-2.52, -0.54)]. After accounting for relevant variables, the association remained significant in women [β=-0.95 (-1.87, -0.03)], but not in men [β=-0.63 (-1.55,0.28)].
This study highlights the significant association between osteoporosis and the physical component of QoL in both older men and women, particularly among women. Further research and interventions focusing on enhancing physical QoL in individuals with osteoporosis are warranted to promote healthier aging.
骨质疏松症是一个日益严重的公共健康问题，尤其是在老年人群中。本研究旨在评估骨质疏松症与老年人样本生活质量（QoL）之间的关联。
本横断面研究利用 Bushehr 老年人健康计划（BEHP）第二阶段所有参与者的数据。使用 12 项简明健康调查问卷（SF-12 问卷）评估 QoL，根据世界卫生组织诊断标准将参与者分为骨质疏松症组和非骨质疏松症组。估计 QoL 的身体成分（PCS）和心理成分（MCS）综合评分。考虑到各种健康和生活方式因素，使用线性回归分析分别评估男性和女性中骨质疏松症与 QoL 的关联。
研究纳入了 2399 名参与者（平均年龄 71.27±7.36 岁），其中 1246 名为女性，1153 名为男性。女性中骨质疏松症的患病率为 59%，男性为 23%。与非骨质疏松症组相比，骨质疏松症组参与者的 PCS 评分显著较低（女性：38.1 分 vs. 40.2 分，p<0.001；男性：44.3 分 vs. 45.8 分，p=0.002），但 MCS 评分无统计学差异。按性别分层后，骨质疏松症与女性 PCS 显著相关[β=-2.14（-3.13，-1.15）]和男性 PCS 显著相关[β=-1.53（-2.52，-0.54）]。在考虑相关变量后，女性的关联仍然显著[β=-0.95（-1.87，-0.03）]，而男性则不显著[β=-0.63（-1.55，0.28）]。
本研究强调了骨质疏松症与男性和女性老年人 QoL 中身体成分的显著关联，尤其是女性。需要进一步研究和干预措施，以提高骨质疏松症患者的身体 QoL，促进更健康的老龄化。
