McKetta Department of Chemical Engineering, The University of Texas at Austin, 200 E Dean Keeton St. Stop C0400, Austin, TX, 78712, USA.
Institute for Cellular and Molecular Biology, The University of Texas at Austin, 2500 Speedway Avenue, Austin, TX, 78712, USA.
Appl Microbiol Biotechnol. 2019 Dec;103(23-24):9251-9262. doi: 10.1007/s00253-019-10200-x. Epub 2019 Nov 4.
Microbial production of fuels and chemicals offers a means by which sustainable product manufacture can be achieved. In this regard, Yarrowia lipolytica is a unique microorganism suitable for a diverse array of biotechnological applications. As a robust oleaginous yeast, it has been well studied for production of fuels and chemicals derived from fatty acids. However, thanks in part to newfound genetic tools and metabolic understanding, Y. lipolytica has been explored for high-level production of a variety of non-lipid products. This mini-review will discuss some of the recent research surrounding the ability of Y. lipolytica to support bio-based chemical production outside the realm of fatty acid metabolism including polyketides, terpenes, carotenoids, pentose phosphate-derived products, polymers, and nanoparticles.
微生物生产燃料和化学品为可持续产品制造提供了一种手段。在这方面，解脂耶氏酵母是一种独特的微生物，适合各种生物技术应用。作为一种强壮的油脂酵母，它已被广泛研究用于生产源自脂肪酸的燃料和化学品。然而，部分由于新发现的遗传工具和代谢理解，解脂耶氏酵母已被探索用于各种非脂类产品的高水平生产。本综述将讨论解脂耶氏酵母在脂肪酸代谢以外的生物基化学品生产方面的一些最新研究，包括聚酮、萜烯、类胡萝卜素、戊糖磷酸衍生产物、聚合物和纳米颗粒。
