School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran.
Department of Chemistry, Sharif University of Technology, Tehran, Iran.
Biomed Microdevices. 2019 Nov 4;21(4):93. doi: 10.1007/s10544-019-0439-0.
Microfluidic systems (MFS) provide a range of advantages in biomedical applications, including improved controllability of material characteristics and lower consumption of reagents, energy, time and money. Fabrication of MFS employs various materials, such as glass, silicon, ceramics, paper, and metals such as gold, copper, aluminum, chromium and titanium. In this review, gold thin film microfluidic channels (GTFMFC) are discussed with reference to fabrication methods and their diverse use in chemical and biomedical applications. The advantages of gold thin films (GTF) include flexibility, ease of manufacture, adhesion to polymer surfaces, chemical stability, good electrical conductivity, surface plasmon resonance effects, ability to be chemically functionalized, etc. Various electroactuators and electroanalytical devices can incorporate GTF. GTF-based MFS have been used in environmental monitoring, assays of biomarkers, immunoassays, cell culture studies and pathogen identification.
微流控系统（MFS）在生物医学应用中提供了一系列优势，包括对材料特性的更好控制以及试剂、能源、时间和金钱的消耗更低。MFS 的制造采用了各种材料，如玻璃、硅、陶瓷、纸张以及金、铜、铝、铬和钛等金属。在本综述中，讨论了金薄膜微流控通道（GTFMFC），并参考了它们的制造方法及其在化学和生物医学应用中的多种用途。金薄膜（GTF）的优点包括灵活性、易于制造、与聚合物表面的附着力、化学稳定性、良好的导电性、表面等离子体共振效应、能够进行化学功能化等。各种电动执行器和电化学生物传感器可以采用 GTF。基于 GTF 的 MFS 已用于环境监测、生物标志物检测、免疫测定、细胞培养研究和病原体鉴定。
