Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan, P. R. China.
Nat Prod Res. 2021 Sep;35(18):3114-3119. doi: 10.1080/14786419.2019.1684281. Epub 2019 Nov 5.
A new indoloditerpene () and fifteen known compounds (-) were isolated from a marine-derived fungus ZZ761. Structure of the new compound was elucidated as (3 ,9,12,13,17,18)-2-carbonyl-3-hydroxylemeniveol based on its HRESIMS data, NMR spectroscopic analyses, the Mosher's method, and ECD calculation. This new indoloditerpene () showed antimicrobial activities with MIC values of 20.6 μM against and 22.8 μM against . Diorcinol () and versicolorin B () had activities in inhibiting the proliferation of human glioma U87MG and U251 cells with IC values of 4.4 and 6.2 μM and 11.3 and 30.5 μM, respectively.
从海洋来源的真菌 ZZ761 中分离得到一个新的吲哚二萜（）和十五个已知化合物（-）。根据其 HRESIMS 数据、NMR 谱分析、Mosher 法和 ECD 计算，新化合物的结构被阐明为（3，9，12，13，17，18）-2-羰基-3-羟基埃门内醇。这种新的吲哚二萜（）对和的 MIC 值分别为 20.6 μM 和 22.8 μM，显示出抗菌活性。二乔醇（）和变色曲菌素 B（）对人神经胶质瘤 U87MG 和 U251 细胞的增殖具有抑制活性，IC 值分别为 4.4 和 6.2 μM 和 11.3 和 30.5 μM。
