Ocean College, Zhoushan Campus , Zhejiang University , Zhoushan 316021 , People's Republic of China.
J Nat Prod. 2019 Oct 25;82(10):2800-2808. doi: 10.1021/acs.jnatprod.9b00481. Epub 2019 Oct 4.
The new streptoglutarimides A-J (-) and the known streptovitacin A () were isolated from a marine-derived actinomycete, sp. ZZ741. Structures of the isolated compounds were elucidated based on their HRESIMS data, extensive NMR spectroscopic analyses, ECD calculations, Mosher's method, and a single-crystal X-ray diffraction experiment. Streptoglutarimide H () and streptovitacin A () showed potent antiproliferative activity against human glioma U87MG and U251 cells with IC values of 1.5-3.8 μM for and 0.05-0.22 μM for . All isolated compounds exhibited antimicrobial activity with MIC values of 9-11 μg/mL against methicillin-resistant , 8-12 μg/mL against , and 8-20 μg/mL against .
新型链二孢菌素 A-J(-)和已知的链维菌素 A()从海洋来源的放线菌， 中分离得到。 sp. ZZ741。根据它们的 HRESIMS 数据、广泛的 NMR 光谱分析、ECD 计算、Mosher 法和单晶 X 射线衍射实验，确定了分离化合物的结构。链二孢菌素 H()和链维菌素 A()对人神经胶质瘤 U87MG 和 U251 细胞表现出强烈的增殖抑制活性，IC 值分别为 1.5-3.8 μM 和 0.05-0.22 μM。所有分离得到的化合物均表现出抗微生物活性，对耐甲氧西林的金黄色葡萄球菌的 MIC 值为 9-11 μg/mL，对 的 MIC 值为 8-12 μg/mL，对 的 MIC 值为 8-20 μg/mL。
