Prenylated Diphenyl Ethers from the Marine Algal-Derived Endophytic Fungus .

Considerable attention has been paid to marine derived endophytic fungi, owing to their capacity to produce novel secondary metabolites with potent bioactivities. In this study, two new compounds with a prenylated diphenyl ether structure-diorcinol L () and ()-diorcinol B ()-were isolated from the marine algal-derived endophytic fungus , along with seven known compounds: ()-diorcinol B (), 9-acetyldiorcinol B (), diorcinol C (), diorcinol D (), diorcinol E (), diorcinol J (), and a dihydrobenzofuran derivative . Their structures were elucidated by extensive NMR spectroscopy studies. Compound represents the first example of an -configuration in the prenylated moiety. All these isolated compounds were examined for antimicrobial and cytotoxic activities. Compounds ⁻ exhibited antimicrobial activities against some human- and plant-pathogenic microbes with MIC values ranging from 2 to 64 μg/mL. Moreover, compound displayed considerable inhibitory activity against the THP-1 cell line in vitro, with an IC value of 7.0 μg/mL.