Department of Radiation Oncology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Divisions of Urology, Department of Surgery, Chang Gung Memorial Hospital, Keelung, Taiwan.
Int J Chron Obstruct Pulmon Dis. 2019 Aug 22;14:1913-1921. doi: 10.2147/COPD.S210975. eCollection 2019.
Chronic obstructive pulmonary disease (COPD) is a major pulmonary disease. However, few studies have investigated the relationship between COPD and prostate cancer (PCa). This study aimed to investigate the association between COPD severity and PCa risk.
We conducted a nationwide population-based cohort study utilizing data from 2001 to 2013 from the National Health Insurance Research Database of Taiwan. Cox proportional hazards models with 1:1 propensity score-matched analysis were used to investigate the association between COPD and PCa risk. We further divided the COPD group according to severe complications (including acute respiratory failure, cardiopulmonary arrest, pneumonia, and acute exacerbation) to test for the relationship between COPD severity and PCa risk.
This study included 47,634 patients (23,817 COPD patients and 23,817 matched non-COPD controls). Among them, 756 (1.59%) were diagnosed with PCa during a mean follow-up period of 7.05±4.13 years; 387 (1.62%) were from the COPD group and 369 (1.55%) were from the control group. Compared with the patients without COPD, the adjusted hazard ratio (HR) for PCa in the COPD patients was 1.10 (95% confidence interval [CI] 0.95-1.27), while that in the COPD patients with complications was 2.46 (95% CI 1.96-3.61).
An increased risk for PCa was found among the COPD patients with complications. COPD complications included acute respiratory failure, cardiopulmonary arrest, pneumonia, and acute exacerbation. These findings may help physicians in treating COPD with complications and in remaining alert to the potential development of PCa.
慢性阻塞性肺疾病（COPD）是一种主要的肺部疾病。然而，很少有研究探讨 COPD 与前列腺癌（PCa）之间的关系。本研究旨在探讨 COPD 严重程度与 PCa 风险之间的关系。
我们利用来自台湾 2001 年至 2013 年的国家健康保险研究数据库进行了一项全国性基于人群的队列研究。使用 Cox 比例风险模型和 1:1 倾向评分匹配分析来探讨 COPD 与 PCa 风险之间的关系。我们进一步根据严重并发症（包括急性呼吸衰竭、心肺骤停、肺炎和急性加重）将 COPD 组进行分组，以检验 COPD 严重程度与 PCa 风险之间的关系。
本研究共纳入 47634 名患者（23817 名 COPD 患者和 23817 名匹配的非 COPD 对照组）。在平均随访 7.05±4.13 年后，有 756 名（1.59%）患者被诊断为 PCa；其中 387 名（1.62%）来自 COPD 组，369 名（1.55%）来自对照组。与无 COPD 的患者相比，COPD 患者的 PCa 调整后危险比（HR）为 1.10（95%置信区间 [CI] 0.95-1.27），而伴有并发症的 COPD 患者的 HR 为 2.46（95% CI 1.96-3.61）。
患有并发症的 COPD 患者发生 PCa 的风险增加。COPD 并发症包括急性呼吸衰竭、心肺骤停、肺炎和急性加重。这些发现可能有助于医生在治疗 COPD 并发症时，并警惕潜在的 PCa 发展。
