Bell J, Adler M W
Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140.
Drug Alcohol Depend. 1988 Jul;21(3):189-94. doi: 10.1016/0376-8716(88)90069-5.
Although it has been known that a morphine abstinence syndrome can be induced by naloxone administered centrally or peripherally, data on a detailed qualitative and quantitative comparison are not available. In the present study morphine pellets were implanted into rats and naloxone was administered intracerebroventricularly (i.c.v.) or subcutaneously (s.c.) 72 h later. A full array of abstinence signs with similar latency, duration, and intensity was seen in morphine-dependent rats following naloxone by either route. There were no major differences in the spectrum of withdrawal signs or in the proportion of rats showing the individual signs. In terms of body weight and temperature, the highest doses tested by each route produced similar quantitative effects. Our results demonstrate that naloxone given i.c.v. can precipitate the full morphine abstinence syndrome in rats at about 1/3 the dose needed for comparable effects when the antagonist is administered s.c.
虽然已知中枢或外周给予纳洛酮可诱发吗啡戒断综合征，但尚无关于详细定性和定量比较的数据。在本研究中，将吗啡丸植入大鼠体内，72小时后经脑室注射（i.c.v.）或皮下注射（s.c.）给予纳洛酮。两种途径给予纳洛酮后，吗啡依赖大鼠均出现了一系列具有相似潜伏期、持续时间和强度的戒断体征。戒断症状谱或出现个体症状的大鼠比例没有重大差异。就体重和体温而言，每种途径测试的最高剂量产生了相似的定量效应。我们的结果表明，经脑室注射给予纳洛酮时，诱发大鼠完全吗啡戒断综合征所需的剂量约为皮下注射该拮抗剂产生可比效应所需剂量的1/3。
