斐济出现基孔肯雅热病毒两年后血清流行率较低。
Low chikungunya virus seroprevalence two years after emergence in Fiji.
机构信息
Institut Louis Malardé, PO BOX 30, 98713 Papeete, Tahiti, French Polynesia.
Fiji Centre for Communicable Disease Control, Tamavua Hospital Complex, Mataika House, Suva, Fiji; The University of the South Pacific, Private Mail Bag, Laucala Campus, Suva, Fiji.
出版信息
Int J Infect Dis. 2020 Jan;90:223-225. doi: 10.1016/j.ijid.2019.10.040. Epub 2019 Nov 2.
OBJECTIVES
In Fiji, autochthonous chikungunya virus (CHIKV) infection was first detected in March 2015. In a previous serosurvey conducted during October-November 2015, we reported a prevalence of anti-CHIKV IgG antibodies of 0.9%. In the present study, we investigated the seroprevalence of CHIKV two years after its emergence in Fiji.
METHODS
Sera from 320 residents of Fiji recruited in June 2017, from the same cohort of individuals that participated in the serosurvey in 2015, were tested for the presence of IgG antibodies against CHIKV using a recombinant antigen-based microsphere immunoassay.
RESULTS
Between 2015 and 2017, CHIKV seroprevalence among residents increased from 0.9% (3/333) to 12.8% (41/320). Of the participants with available serum samples collected in both 2015 and 2017 (n=200), 31 (15.5%) who were seronegative in 2015 had seroconverted to CHIKV in 2017.
CONCLUSIONS
Our findings suggest that low-level transmission of CHIKV occurred during the two years following the emergence of the virus in Fiji. No CHIKV infection has been reported in Fiji since 2017, but due to the presumed low herd immunity of the population, the risk of CHIKV re-emergence is high. Consequently, chikungunya should be considered in the differential diagnosis of acute febrile diseases in Fiji.
目的
2015 年 3 月，斐济首次检测到本地基孔肯雅病毒（CHIKV）感染。在 2015 年 10 月至 11 月进行的先前血清调查中，我们报告了抗 CHIKV IgG 抗体的流行率为 0.9%。在本研究中，我们调查了斐济出现 CHIKV 两年后的血清流行率。
方法
2017 年 6 月，从 2015 年参加血清调查的同一队列中招募了 320 名斐济居民的血清，使用基于重组抗原的微球免疫分析检测针对 CHIKV 的 IgG 抗体的存在。
结果
2015 年至 2017 年间，居民中的 CHIKV 血清流行率从 0.9%（3/333）增加到 12.8%（41/320）。在 2015 年和 2017 年均有可用血清样本的参与者中（n=200），31 名在 2015 年血清阴性的参与者在 2017 年发生了血清转化。
结论
我们的研究结果表明，在斐济病毒出现后的两年中，CHIKV 发生了低水平传播。自 2017 年以来，斐济未报告 CHIKV 感染，但由于人群假定的低群体免疫力，CHIKV 再次出现的风险很高。因此，在斐济急性发热疾病的鉴别诊断中应考虑基孔肯雅热。
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