Medical Research Unit-Zacatecas, Mexican Institute for Social Security-IMSS, Zacatecas, Mexico.
Faculty of Chemistry, University Autonomous of Zacatecas, Mexico.
Microbes Infect. 2020 Apr;22(3):111-118. doi: 10.1016/j.micinf.2019.10.002. Epub 2019 Nov 2.
Diabetes has been associated with an increased risk of developing tuberculosis. The reasons related to the increased susceptibility to develop TB in type 2 diabetes mellitus (T2DM) individuals, has not been completely elucidated. However, this susceptibility has been attributed to several factors including failures and misfunctioning of the immune system. In the present study, we aimed to determine the role of anti-hyperglycemic drugs such as glyburide, insulin, and metformin to promote the killing of mycobacteria through the regulation of innate immune molecules such as host defense peptides (HDP) in lung epithelial cells and macrophages. Our results showed that metformin reduces bacillary loads in macrophages and lung epithelial cells which correlates with higher production of β-defensin-2, -3 and -4. Since β-defensins are crucial molecules for controlling Mycobacteriumtuberculosis growth, the present results suggest that the use of metformin would be the first choice in the treatment for T2DM2, in patients within tuberculosis-endemic areas.
糖尿病与患结核病的风险增加有关。导致 2 型糖尿病（T2DM）患者易患结核病的原因尚未完全阐明。然而，这种易感性归因于多种因素，包括免疫系统的失败和功能障碍。在本研究中，我们旨在确定降糖药物（如格列本脲、胰岛素和二甲双胍）通过调节肺上皮细胞和巨噬细胞中的固有免疫分子（如宿主防御肽（HDP））来促进杀死分枝杆菌的作用。我们的结果表明，二甲双胍可降低巨噬细胞和肺上皮细胞中的细菌负荷，这与 β-防御素-2、-3 和 -4 的产量增加相关。由于 β-防御素是控制结核分枝杆菌生长的关键分子，因此本研究结果表明，在结核病流行地区的 T2DM2 患者中，使用二甲双胍将是首选治疗方法。
