Tuberculosis Prevention and Control Key Laboratory/Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment, Senior Department of Tuberculosis, The 8th Medical Center of PLA General Hospital, Beijing 100091, China.
Hebei North University, Zhangjiakou, 075000 Hebei, China.
J Immunol Res. 2022 Jun 1;2022:6837745. doi: 10.1155/2022/6837745. eCollection 2022.
Tuberculosis (TB) is one of humanity's three major infectious diseases. Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia due to impaired insulin secretion or impaired insulin function. It has been reported that DM is a primary risk factor for TB disease. Given the increasing public health threat to people's health, more and more studies have focused on diabetes complicated by TB. Hyperglycemia can affect the function of human immune cells, promote primary infections and reactivation of TB, and increase the susceptibility and severity of TB. However, the immunological mechanism behind it is still not clear. By reviewing the related articles on tuberculosis complicated with diabetes published in recent years, this paper expounds on the effect of hyperglycemia on innate immunity and adaptive immunity of patients with TB. This review provides new insights for elucidating the immunological mechanism of TB complicated with DM and lays the foundation for finding potential targets for preventing and treating TB combined with DM.
结核病（TB）是人类三大传染病之一。糖尿病（DM）是一种代谢性疾病，其特征是由于胰岛素分泌受损或胰岛素功能受损而导致的高血糖。有报道称，DM 是结核病发病的主要危险因素。鉴于糖尿病对人们健康的公共卫生威胁日益增加，越来越多的研究集中在糖尿病并发结核病上。高血糖会影响人体免疫细胞的功能，促进 TB 的原发感染和再激活，并增加 TB 的易感性和严重程度。然而，其背后的免疫学机制尚不清楚。通过对近年来发表的关于糖尿病并发结核病的相关文章进行综述，本文阐述了高血糖对 TB 患者固有免疫和适应性免疫的影响。该综述为阐明 DM 合并 TB 的免疫学机制提供了新的见解，并为寻找预防和治疗 DM 合并 TB 的潜在靶点奠定了基础。
