幽门螺杆菌感染与非酒精性脂肪肝之间的关联：一项荟萃分析。
Association between Helicobacter pylori infection and nonalcoholic fatty liver: A meta-analysis.
作者信息
Liu Rongqiang, Liu Qiuli, He Ying, Shi Wenqing, Xu Qianhui, Yuan Qing, Lin Qi, Li Biao, Ye Lei, Min Youlan, Zhu Peiwen, Shao Yi
机构信息
Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi.
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangzhou Medical University.
出版信息
Medicine (Baltimore). 2019 Nov;98(44):e17781. doi: 10.1097/MD.0000000000017781.
BACKGROUND
Opinion regarding whether Helicobacter pylori infection can promote the occurrence and development of nonalcoholic fatty liver (NAFLD) is divided. Therefore, we aimed to assess the exact relationship between H pylori infection and NAFLD by integrating all available data.
METHODS
The articles about H pylori infection and NAFLD were collected by searching the databases of PubMed, Embase, Web of Science, Scopus, China National Knowledge Infrastructure, and WanFang. The random-effects model was used for data analysis, followed by subgroup analysis and meta-regression to explore sources of heterogeneity.
RESULTS
Twenty-one articles were included in the study. Pooled analysis showed that H pylori infection indeed promoted NAFLD. Subgroup analysis and regression analysis showed that case-control ratio may be one of the sources of heterogeneity.
CONCLUSIONS
H pylori infection is indeed one of the factors that promotes the progression of NAFLD for the Asian population. This provides new approaches for clinical prevention and treatment for NAFLD.
背景
关于幽门螺杆菌感染是否会促进非酒精性脂肪肝（NAFLD）的发生和发展，观点存在分歧。因此，我们旨在通过整合所有可用数据来评估幽门螺杆菌感染与NAFLD之间的确切关系。
方法
通过检索PubMed、Embase、Web of Science、Scopus、中国知网和万方数据库，收集有关幽门螺杆菌感染和NAFLD的文章。采用随机效应模型进行数据分析，随后进行亚组分析和Meta回归以探索异质性来源。
结果
该研究纳入了21篇文章。汇总分析表明，幽门螺杆菌感染确实会促进NAFLD的发生。亚组分析和回归分析表明，病例对照比可能是异质性来源之一。
结论
幽门螺杆菌感染确实是亚洲人群中促进NAFLD进展的因素之一。这为NAFLD的临床预防和治疗提供了新的途径。
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