West China School of Nursing, Sichuan University/West China Hospital, Sichuan University, 37 Guo Xue Rd., Chengdu 610041, China.
Department of Organization, West China Hospital, Sichuan University, 37 Guo Xue Rd., Chengdu 610041, China.
Nutrients. 2022 Sep 9;14(18):3726. doi: 10.3390/nu14183726.
In recent years, there has been growing concern about the impact of the gastrointestinal microbiome on human health outcomes. To clarify the evidence for a link between the gastrointestinal microbiome and a variety of health outcomes in humans, we conducted an all-encompassing review of meta-analyses and systematic reviews that included 195 meta-analyses containing 950 unique health outcomes. The gastrointestinal microbiome is related to mortality, gastrointestinal disease, immune and metabolic outcomes, neurological and psychiatric outcomes, maternal and infant outcomes, and other outcomes. Existing interventions for intestinal microbiota (such as probiotics, fecal microbiota transplant, etc.) are generally safe and beneficial to a variety of human health outcomes, but the quality of evidence is not high, and more detailed and well-designed randomized controlled trials are necessary.
近年来，人们越来越关注胃肠道微生物组对人类健康结果的影响。为了阐明胃肠道微生物组与人类各种健康结果之间的关联证据，我们对包括 195 项荟萃分析和系统评价在内的meta 分析和系统评价进行了全面综述，其中包含 950 个独特的健康结果。胃肠道微生物组与死亡率、胃肠道疾病、免疫和代谢结果、神经和精神结果、母婴结果以及其他结果有关。现有的肠道微生物群干预措施（如益生菌、粪便微生物移植等）通常对各种人类健康结果是安全且有益的，但证据质量不高，需要更详细和精心设计的随机对照试验。
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