Marneros A, Deister A, Rohde A, Jünemann H, Fimmers R
Psychiatric Department, University of Bonn, Federal Republic of Germany.
Eur Arch Psychiatry Neurol Sci. 1988;237(5):264-75. doi: 10.1007/BF00450545.
The present study (Cologne study) investigated the long-term course (means = 25.6 years, minimum 10, maximum 59 years) of 72 schizoaffective patients. The diagnosis was based on the longitudinal approach. All patients were interviewed personally, using the Present State Examination and a pool of questions based on some instruments of the WHO (DAS, PIRS, etc.). The course was found to be usually polyphasic (more than 3 episodes) and only exceptionally monophasic (1 episode). For the purposes of statistical analysis an episode was considered in terms of time between the beginning and ending of inpatient or inpatient-like treatment. The number of episodes and cycles were found to be independent from premorbid and sociodemographic variables. But a significant relation was found between number of episodes (and cycles) and (a) polarity of the affective symptomatology, (b) presence of psychotic productive symptoms, (c) polymorphous course, (d) age at onset, and (e) duration of activity of the illness. It can be said that schizoaffective disorders are recurrent whereby the frequency of relapses is higher in bipolar than in unipolar types.
本研究（科隆研究）调查了72例分裂情感性障碍患者的长期病程（平均25.6年，最短10年，最长59年）。诊断基于纵向研究方法。所有患者均接受了个人访谈，采用《现状检查》以及基于世界卫生组织的一些工具（残疾评定量表、现状症状评定量表等）设计的一系列问题。结果发现病程通常为多相性（超过3次发作），仅在极少数情况下为单相性（1次发作）。为了进行统计分析，发作被定义为住院治疗或类似住院治疗开始至结束之间的时间段。发作次数和发作周期与病前及社会人口统计学变量无关。但发现发作次数（和发作周期）与以下因素之间存在显著关系：（a）情感症状的极性，（b）精神病性阳性症状的存在，（c）多形性病程，（d）发病年龄，以及（e）疾病活动持续时间。可以说，分裂情感性障碍具有复发性，双相型的复发频率高于单相型。
