Department of Internal Medicine, Division of Renal Disease and Hypertension, University of Colorado/Anschutz Medical Center, Aurora, CO, USA.
Division of Renal Diseases & Hypertension, Aurora, CO, USA
Perit Dial Int. 2019 Nov-Dec;39(6):568-570. doi: 10.3747/pdi.2019.00247.
Bacterial peritonitis continues to be a significant cause of morbidity and mortality in patients undergoing peritoneal dialysis. Episodes of peritonitis due to coagulase-negative staphylococci (CNS) are especially prone to relapse or repeat, often culminating in catheter removal and technique failure. This pattern is thought to be associated with the production of a biofilm that offers protection against antimicrobials and the host defense systems. We report the successful eradication of repeated episodes of CNS peritonitis using an aggressive multipronged therapeutic approach combining several antibiotics and a thrombolytic agent.
细菌性腹膜炎仍然是腹膜透析患者发病率和死亡率的重要原因。凝固酶阴性葡萄球菌（CNS）引起的腹膜炎尤其容易复发或再次发生，通常最终导致导管移除和技术失败。这种模式被认为与生物膜的产生有关，生物膜可以提供对抗生素和宿主防御系统的保护。我们报告了使用一种积极的多管齐下的治疗方法成功根除了反复发作的 CNS 腹膜炎，该方法结合了几种抗生素和溶栓剂。
