College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang 310000, China.
Nucleic Acids Res. 2020 Jan 8;48(D1):D1031-D1041. doi: 10.1093/nar/gkz981.
Knowledge of therapeutic targets and early drug candidates is useful for improved drug discovery. In particular, information about target regulators and the patented therapeutic agents facilitates research regarding druggability, systems pharmacology, new trends, molecular landscapes, and the development of drug discovery tools. To complement other databases, we constructed the Therapeutic Target Database (TTD) with expanded information about (i) target-regulating microRNAs and transcription factors, (ii) target-interacting proteins, and (iii) patented agents and their targets (structures and experimental activity values if available), which can be conveniently retrieved and is further enriched with regulatory mechanisms or biochemical classes. We also updated the TTD with the recently released International Classification of Diseases ICD-11 codes and additional sets of successful, clinical trial, and literature-reported targets that emerged since the last update. TTD is accessible at http://bidd.nus.edu.sg/group/ttd/ttd.asp. In case of possible web connectivity issues, two mirror sites of TTD are also constructed (http://db.idrblab.org/ttd/ and http://db.idrblab.net/ttd/).
治疗靶点和早期药物候选物的知识对于改进药物发现是有用的。特别是关于靶标调节剂和专利治疗剂的信息，有助于研究可药性、系统药理学、新趋势、分子景观以及药物发现工具的开发。为了补充其他数据库，我们构建了治疗靶点数据库（TTD），其中包含有关（i）靶标调节 microRNA 和转录因子、（ii）靶标相互作用蛋白以及（iii）专利药物及其靶标的扩展信息（如果有，还包括结构和实验活性值），这些信息可以方便地检索，并进一步丰富了调控机制或生化类别。我们还使用最近发布的国际疾病分类 ICD-11 代码以及自上次更新以来出现的成功临床试验和文献报道的目标数据集更新了 TTD。TTD 可在 http://bidd.nus.edu.sg/group/ttd/ttd.asp 访问。如果可能存在网络连接问题，我们还构建了 TTD 的两个镜像站点（http://db.idrblab.org/ttd/ 和 http://db.idrblab.net/ttd/）。
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