Centre for Discovery Brain Science, Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.
School of Life Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, UK.
Nucleic Acids Res. 2024 Jan 5;52(D1):D1438-D1449. doi: 10.1093/nar/gkad944.
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb; https://www.guidetopharmacology.org) is an open-access, expert-curated, online database that provides succinct overviews and key references for pharmacological targets and their recommended experimental ligands. It includes over 3039 protein targets and 12 163 ligand molecules, including approved drugs, small molecules, peptides and antibodies. Here, we report recent developments to the resource and describe expansion in content over the six database releases made during the last two years. The database update section of this paper focuses on two areas relating to important global health challenges. The first, SARS-CoV-2 COVID-19, remains a major concern and we describe our efforts to expand the database to include a new family of coronavirus proteins. The second area is antimicrobial resistance, for which we have extended our coverage of antibacterials in partnership with AntibioticDB, a collaboration that has continued through support from GARDP. We discuss other areas of curation and also focus on our external links to resources such as PubChem that bring important synergies to the resources.
IUPHAR/BPS 药理学指南（GtoPdb；https://www.guidetopharmacology.org）是一个开放获取的、专家编辑的在线数据库，为药理学靶点及其推荐的实验配体提供简洁的概述和关键参考。它包含超过 3039 个蛋白质靶点和 12163 个配体分子，包括已批准的药物、小分子、肽和抗体。在这里，我们报告了该资源的最新进展，并描述了在过去两年中进行的六次数据库更新中内容的扩展。本文数据库更新部分重点介绍了与两个重要的全球健康挑战相关的两个领域。第一个是 SARS-CoV-2 COVID-19，仍然是一个主要关注点，我们描述了我们努力扩展数据库以包括冠状病毒蛋白的一个新家族。第二个领域是抗菌素耐药性，为此我们与 AntibioticDB 合作扩展了抗菌药物的覆盖范围，该合作通过 GARDP 的支持得以延续。我们讨论了其他编辑领域，并重点介绍了我们与 PubChem 等资源的外部链接，这些链接为资源带来了重要的协同作用。
