Parinandi N L, Schmid H H
Hormel Institute, University of Minnesota, Austin 55912.
FEBS Lett. 1988 Sep 12;237(1-2):49-52. doi: 10.1016/0014-5793(88)80169-8.
A long-chain N-acylethanolamine (N-oleoyl-2-aminoethanol) is shown to inhibit the production of thiobarbituric acid-reactive substances in rat heart mitochondria treated with Fe2+ or Fe3+/ADP. The inhibition is concentration-dependent in the range 50-150 microM of the agent and can be nearly complete depending on the type and amount of the free radical-generating system. Structural analogues of N-acylethanolamine are inhibitory as well, but neither oleic acid nor ethanol-amine has measurable effects. N-Oleoyl-2-aminoethanol affects peroxidation of linoleic acid micelles only minimally and has no effect on deoxyribose peroxidation.
一种长链N-酰基乙醇胺（N-油酰基-2-氨基乙醇）被证明可抑制用Fe2+或Fe3+/ADP处理的大鼠心脏线粒体中硫代巴比妥酸反应性物质的产生。在50-150微摩尔该试剂范围内，抑制作用呈浓度依赖性，并且根据自由基产生系统的类型和量，抑制作用几乎可以完全实现。N-酰基乙醇胺的结构类似物也具有抑制作用，但油酸和乙醇胺均无明显作用。N-油酰基-2-氨基乙醇对亚油酸微团的过氧化作用影响极小，对脱氧核糖过氧化作用无影响。
