p16：偏离常规的循环。
p16: cycling off the beaten path.
作者信息
Buj Raquel, Aird Katherine M
机构信息
Department of Cellular & Molecular Physiology, Penn State College of Medicine, Hershey, PA, USA.
出版信息
Mol Cell Oncol. 2019 Oct 15;6(6):e1677140. doi: 10.1080/23723556.2019.1677140. eCollection 2019.
Abstract
p16 (hereafter called p16) is a faithful cellular ally in the fight against tumorigenesis. Although its canonical pathway through retinoblastoma (RB) is well delineated, RB-independent functions for p16 are beginning to emerge. Here we summarize non-canonical roles of p16, including our recent finding on its role in nucleotide metabolism.
摘要
p16（以下称为p16）是对抗肿瘤发生的可靠细胞伙伴。尽管其通过视网膜母细胞瘤（RB）的经典途径已得到充分阐明，但p16不依赖RB的功能也开始显现。在此，我们总结p16的非经典作用，包括我们最近关于其在核苷酸代谢中作用的发现。
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