Hatzis J, Gourgiotou K, Tosca A, Varelzidis A, Stratigos J
Department of Dermatology and Venereology, University of Athens, A. Sygros Hospital, Greece.
Dermatologica. 1988;177(3):146-8. doi: 10.1159/000248532.
During the topical treatment of 45 patients, who had extensive forms of alopecia areata, with the allergen diphencyprone, 3 of them (6.7%) developed vitiligo. Two were females and 1 male aged 53, 19 and 28 years respectively. None of these patients had a personal or family history of vitiligo. Vitiligo appeared 3-5 months after the onset of treatment and was localized only to the areas of topical application in the younger woman and the man. In the older woman, vitiligo extended to several areas apart from those where the medicament was applied. After the end of diphencyprone treatment, vitiligo had a spontaneous significant improvement only in the man. Mitochondrial autoantibodies were found in the older woman only. To our knowledge, vitiligo due to diphencyprone has not been previously reported.
在对45例患有广泛型斑秃的患者进行外用变应原二苯环丙烯酮治疗期间，其中3例（6.7%）出现了白癜风。2例为女性，1例为男性，年龄分别为53岁、19岁和28岁。这些患者均无白癜风个人史或家族史。白癜风在治疗开始后3 - 5个月出现，在较年轻的女性和男性中仅局限于外用药物的部位。在老年女性中，白癜风除了药物涂抹部位外还扩展到了其他几个部位。二苯环丙烯酮治疗结束后，仅男性患者的白癜风有自发的显著改善。仅在老年女性中发现了线粒体自身抗体。据我们所知，此前尚未有二苯环丙烯酮导致白癜风的报道。
