输血器对红细胞溶血的影响。

Effects of Blood Transfusion Sets on Red Blood Cell Hemolysis.

作者信息

Pardo Larissa Perez, Kusahara Denise Miyuki, Pires Maria Paula de Oliveira, Nani Luiz Augusto Silva, Avelar Ariane Ferreira Machado, Peterlini Maria Angélica Sorgini, Pedreira Mavilde Luz Gonçalves

机构信息

Universidade Federal de São Paulo, São Paulo, Brazil (Mss Pardo and Drs Pires, Avelar, Kusahara, Peterlini, and Pedreira); Paulista University, São Paulo, Brazil (Ms Pardo and Pires); The Alliance for Vascular Access Teaching and Research (AVATAR) Group, Menzies Health Institute Queensland at Griffith University, Brisbane, Queensland, Australia (Ms Pires); Colsan Blood Collection Association, São Paulo, Brazil (Mr Nani). Larissa Perez Pardo, MSN, RN, is an adjunct professor of nursing at Paulista University and a PhD candidate in the Paulista School of Nursing at the Universidade Federal de São Paulo. Denise Miyuki Kusahara, PhD, RN, is an adjunct professor at Universidade Federal de São Paulo-Brazil. Maria Paula de Oliveira Pires, PhD, RN, is an adjunct professor in nursing at Paulista University. She is also an adjunct research fellow at Universidade Federal de São Paulo and the AVATAR group Menzies Health Institute Queensland at Griffith University in Brisbane, Australia. Luiz Augusto Silva Nani, BS, is a biologist specialist in clinical and toxicological analyses, and laboratory supervisor of the blood components quality control at Colsan Blood Collection Association in São Paulo, Brazil. Ariane Ferreira Machado Avelar, PhD, RN, is an associate professor at the Universidade Federal de São Paulo-Brazil. Maria Angélica Sorgini Peterlini, PhD, RN, is associate professor at the Federal University of São Paulo. Mavilde Luz Gonçalves Pedreira, PhD, RN, is associate professor at the Federal University of São Paulo.

出版信息

J Infus Nurs. 2019 Nov/Dec;42(6):303-310. doi: 10.1097/NAN.0000000000000346.

DOI:10.1097/NAN.0000000000000346

PMID:31693564

Abstract

This experimental randomized study compared the effects of macrodrop and microdrop blood transfusion sets on red blood cell (RBC) hemolysis. Twenty units of packed RBCs from different donors were infused through 48 infusion sets from 2 manufacturers at infusion rates of 10 and 100 mL/h. Pre- and postinfusion analysis was performed to determine total hemoglobin (g/dL), hematocrit (%), free hemoglobin (g/dL), potassium (mmol/L), haptoglobin (g/L), and degree of hemolysis (%). The results demonstrated that the level of free hemoglobin (P < .001) and degree of hemolysis (P < .001) increased postinfusion. A higher degree of hemolysis was noted when the RBCs were infused at a rate of 10 mL/h through a microdrop blood transfusion set.

摘要

这项实验性随机研究比较了大滴和小滴输血装置对红细胞（RBC）溶血的影响。来自不同供血者的20单位浓缩红细胞通过2家制造商生产的48套输液装置，以10和100 mL/h的输注速度进行输注。输注前后进行分析，以测定总血红蛋白（g/dL）、血细胞比容（%）、游离血红蛋白（g/dL）、钾（mmol/L）、触珠蛋白（g/L）和溶血程度（%）。结果表明，输注后游离血红蛋白水平（P < .001）和溶血程度（P < .001）升高。当红细胞以10 mL/h的速度通过小滴输血装置输注时，观察到更高程度的溶血。