From the Departments of Nuclear Medicine.
Internal Medicine.
Clin Nucl Med. 2020 Feb;45(2):e106-e107. doi: 10.1097/RLU.0000000000002818.
Graft versus host disease (GVHD) is the most frequent and serious complication of allogenic hematopoietic stem cell transplant. Polymyositis is a rare neuromuscular manifestation of GVHD, which often responds well to corticosteroid and immunosuppression therapy. We present a case of a 38-year-old man with a known case of mixed-phenotype acute leukemia after hematopoietic stem cell transplant presenting with GVHD-associated polymyositis. F-FDG PET/CT done in this case not only helped in the detection of the muscle involvement but also helped in obtaining precise muscle sample for histopathological diagnosis using PET-guided biopsy.
移植物抗宿主病（GVHD）是异基因造血干细胞移植后最常见和最严重的并发症。多发性肌炎是 GVHD 的一种罕见神经肌肉表现，通常对皮质类固醇和免疫抑制治疗反应良好。我们报告了一例 38 岁男性，患有混合表型急性白血病，造血干细胞移植后出现 GVHD 相关多发性肌炎。该病例中的 F-FDG PET/CT 不仅有助于检测肌肉受累，还通过 PET 引导活检帮助获得精确的肌肉样本进行组织病理学诊断。
