Parida Girish Kumar, Upadhyay Amitabh, Mitra Sujata, Suman Akchata, Muthu Gopal Sonai
Department of Nuclear Medicine and PET-CT, Tata Main Hospital, Jamshedpur, Jharkhand, India.
Department of Medical Oncology, Tata Main Hospital, Jamshedpur, Jharkhand, India.
Indian J Nucl Med. 2020 Jul-Sep;35(3):248-250. doi: 10.4103/ijnm.IJNM_25_20. Epub 2020 Jul 1.
We report an extremely rare case of acute inflammatory myopathy during combination chemotherapy with docetaxel and transtuzumab for metastatic breast carcinoma in a 44-year-old female patient. Despite the significant response in the follow-up fluorodeoxyglucose (FDG) positron emission tomography/computed tomography, of the underlying malignancy to the chemotherapeutic regimen, there was diffusely increased FDG uptake in the upper and lower limb muscles with associated painful, proximal muscle weakness. These symptoms regressed after the discontinuation of docetaxel and the administration of corticosteroids, suggesting it to be the drug-induced myositis.
我们报告了一例极为罕见的病例，一名44岁女性患者在接受多西他赛和曲妥珠单抗联合化疗治疗转移性乳腺癌期间发生急性炎症性肌病。尽管在后续的氟脱氧葡萄糖（FDG）正电子发射断层扫描/计算机断层扫描中显示，基础恶性肿瘤对化疗方案有显著反应，但患者上肢和下肢肌肉的FDG摄取弥漫性增加，并伴有疼痛性近端肌无力。停用多西他赛并给予皮质类固醇后，这些症状有所缓解，提示为药物性肌炎。
