Cicciarelli J C, Chia D, Terasaki P I, Barnett E V, Shirahama S
Transplant Proc. 1979 Dec;11(4):1950-3.
Cytotoxic antibodies to B lymphocytes have been shown to be IgM. They are not absorbed by red blood cells and therefore not absorbed by red blood cells and therefore not directed against the I antigen of red cells. They are also not inhibited by mannose, as are certain natural cytotoxins against lymphocytes. Methods for producing purified eluates of IgM anti-IgM antibodies are given. These antibodies are postulated to be immunoregulative by acting on B lymphocytes.
已证明针对B淋巴细胞的细胞毒性抗体为IgM。它们不会被红细胞吸附，因此不是针对红细胞I抗原的。它们也不像某些针对淋巴细胞的天然细胞毒素那样被甘露糖抑制。文中给出了制备IgM抗IgM抗体纯化洗脱液的方法。推测这些抗体通过作用于B淋巴细胞发挥免疫调节作用。
