Takahashi H, Terasaki P I, Iwaki Y, Nakata S
Tissue Antigens. 1980 Aug;16(2):176-80. doi: 10.1111/j.1399-0039.1980.tb00599.x.
IgG and IgM were stripped from the surface of human B lymphocytes using heterologous anti-IgG or IgM antisera. The percent SIg (surface Ig) determined by fluorescence for SIgM was reduced from 55% to 20%, or a reduction of 64%. Upon stripping SIgM, the B lymphocytes were no longer killed by seven different cold cytotoxic antibodies obtained from kidney transplant patients. We conclude that SIgM is the target of cold cytotoxins. These cold cytotoxic antibodies are postulated to be immunoregulatory antibodies. They are less specific than anti-idiotypic antibodies.
使用异源抗IgG或IgM抗血清从人B淋巴细胞表面去除IgG和IgM。通过荧光测定的表面IgM（SIgM）百分比从55%降至20%，即降低了64%。去除SIgM后，B淋巴细胞不再被从肾移植患者获得的七种不同的冷细胞毒性抗体杀死。我们得出结论，SIgM是冷细胞毒素的靶标。这些冷细胞毒性抗体被假定为免疫调节抗体。它们比抗独特型抗体特异性更低。
