利多卡因可逆性失活杏仁中央核损害大鼠吗啡状态依赖学习的获得、巩固和提取。
Lidocaine Reversible Inactivation of the Central Nucleus of Amygdala Impairs Acquisition, Consolidation, and Retrieval of Morphine State-Dependent Learning in Rat.
机构信息
Department of Plant and Animal Biology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran,
Department of Plant and Animal Biology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
出版信息
Pharmacology. 2020;105(3-4):225-230. doi: 10.1159/000503726. Epub 2019 Nov 6.
BACKGROUND/AIMS: Morphine causes state-dependent learning that its mechanism and brain-related structures are not fully understood. This study aimed to determine whether lidocaine reversible inactivation of the central nucleus of the amygdala (CeA) could affect acquisition, consolidation, and retrieval of morphine state-dependent learning.
METHODS
One hundred twenty male Wistar rats were allocated into 15 experimental groups. Subcutaneous administration of morphine (5 mg/kg) induced morphine state-dependent learning. Intra-CeA injection of Lidocaine hydrochloride was performed 5 min before each morphine session for transient inactivation of the CeA. The step-through latency and the time spent in the dark compartment were measured using passive avoidance learning task.
RESULTS
Our results showed that pretraining, posttraining, and pretest inhibition of the CeA severely impaired acquisition, consolidation, and retrieval of morphine state-dependent learning.
CONCLUSION
These data revealed the involvement of the CeA in different stages of memory and morphine state-dependent learning.
背景/目的：吗啡会引起状态依赖学习，但它的机制和相关脑结构尚未完全了解。本研究旨在确定利多卡因可逆性失活杏仁中央核（CeA）是否会影响吗啡状态依赖学习的获得、巩固和检索。
方法
将 120 只雄性 Wistar 大鼠分为 15 个实验组。皮下给予吗啡（5mg/kg）诱导吗啡状态依赖学习。在每次吗啡治疗前 5 分钟，通过 CeA 内注射盐酸利多卡因，对 CeA 进行短暂失活。使用被动回避学习任务测量步出潜伏期和在暗室中停留的时间。
结果
我们的结果表明，CeA 的预处理、后处理和预测试抑制严重损害了吗啡状态依赖学习的获得、巩固和检索。
结论
这些数据表明 CeA 参与了记忆和吗啡状态依赖学习的不同阶段。
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