Faculty of Medicine, National University of San Marcos, Cangallo 818, 15001 Cercado de Lima, Peru.
National Institute of Child Health, Paediatric Nephrology Service, Avenida Brasil 600, 15083 Breña, Peru.
Nutrients. 2019 Nov 5;11(11):2671. doi: 10.3390/nu11112671.
Zinc is an essential micronutrient for human beings and its deficiency affects their normal growth and development.
The main aim was to evaluate the effect of two doses of zinc supplementation (ZS) on the nutritional status in chronic kidney disease (CKD) children.
A randomized-trial multicentric study was conducted in 48 CKD (23 females) patients under 18-years-old, for a year. At random, participants took 30 or 15 mg/day of ZS, respectively. Anthropometric measurements and biochemical analysis were performed. Hypozincemia was determined by serum zinc concentration (SZC) using atomic absorption spectrophotometry. The positive or negative change in patients' body mass index (BMI) Z-score, serum albumin, zinc and C-reactive protein (CRP) levels were used to evaluate the effect of ZS.
Mean SZC was normal before and after ZS. Despite ZS, there were no significant changes in serum albumin, zinc and CRP levels. A positive and significant association was observed between SZC and serum albumin before ( = 0.000) and after ( = 0.007) ZS. In both groups of ZS, there was a small but positive and significant change in body mass and normalization in BMI Z-score, hypoalbuminemia, hypozincemia and high CRP, especially with 30 mg/day of ZS.
Zinc supplementation may be beneficial for nutritional status in children and adolescents with CKD.
锌是人体必需的微量元素，其缺乏会影响正常生长发育。
评估两种剂量锌补充剂（ZS）对慢性肾脏病（CKD）儿童营养状况的影响。
对 48 名年龄在 18 岁以下的 CKD（23 名女性）患者进行了一项随机试验多中心研究，为期一年。随机给予 30 或 15mg/天的 ZS。进行人体测量和生化分析。使用原子吸收分光光度法测定血清锌浓度（SZC）确定低锌血症。通过患者体重指数（BMI）Z 评分、血清白蛋白、锌和 C 反应蛋白（CRP）水平的正负变化来评估 ZS 的效果。
SZC 在 ZS 前后均正常。尽管进行了 ZS，但血清白蛋白、锌和 CRP 水平没有显著变化。SZC 与 ZS 前后的血清白蛋白呈正相关（=0.000）。在 ZS 的两组中，体重均有较小但显著的变化，BMI Z 评分、低白蛋白血症、低锌血症和高 CRP 得到正常化，尤其是使用 30mg/天的 ZS。
锌补充剂可能对 CKD 儿童和青少年的营养状况有益。
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