Student Scientific Club of Endocrinology, Poznan University of Medical Sciences, Poznań, Wielkopolskie, Poland and District Hospital in Głogów, Dolnośląskie, Poland.
Outpatients Clinic of Endocrine Diseases, Wschowa, Lubuskie, Poland.
Am J Mens Health. 2021 Jul-Aug;15(4):15579883211034984. doi: 10.1177/15579883211034984.
Chemerin (CHEM) is a new proinflammatory adipokine involved in the immune, metabolic and reproductive processes. Low-grade state inflammation (LGSI) is a key element in the pathogenesis of metabolic syndrome (MS). Low SHBG is a good marker of male hypogonadism in MS. This study evaluated the prognostic value of selected adipokine, LGSI, and androgenic parameters in predicting the risk of MS among men. One hundred thirty-two random men aged 40 to 70 years old were enrolled. Measurements of anthropometric indices, blood pressure, and laboratory tests were carried out. A total of 62 men (47%) were diagnosed with MS. Chemerin concentrations were higher in men diagnosed with MS compared to healthy: 89.48 (78.12-112.10) vs. 77.9 (65.12-98.64) ng/mL; = .002. Men diagnosed with MS presented with lower levels of total testosterone: 5.75 (4.00-6.57) vs. 6.40 (5.50-8.40) ng/mL; = .0014 and SHBG: 46.58 (35.13-66.28) vs. 71.97 (56.1-92.7) nM/L; < 0.000001. Elevated LGSI indices were demonstrated in men with MS as opposed to healthy [IL-18: 530.64 (409.12-640.56) vs. 418.85 (348.14-496.44) pg/mL; = .000033 and hs-CRP: 2.15 (0.97-4.26) vs. 1.01 (0.41-2.68) ng/mL; = .0057)]. In multivariate regression analysis, the highest negative predictive value in assessing the risk of MS was SHBG serum concentration, while the highest positive predictive values were: IL-18, hypertriglyceridemia, and waist circumference. Decreased SHBG levels, combined with elevated IL-18 concentrations in men showing hypertriglyceridemic waist phenotype, significantly increase the risk of MS.
趋化素（CHEM）是一种新的促炎脂肪因子，参与免疫、代谢和生殖过程。低度炎症状态（LGSI）是代谢综合征（MS）发病机制中的关键因素。低性激素结合球蛋白（SHBG）是男性 MS 性腺功能减退的良好标志物。本研究评估了选择的脂肪因子、LGSI 和雄激素参数在预测男性 MS 风险中的预后价值。纳入 132 名随机年龄在 40 至 70 岁的男性。进行了人体测量指数、血压和实验室检查的测量。共有 62 名男性（47%）被诊断为 MS。与健康男性相比，诊断为 MS 的男性趋化素浓度更高：89.48（78.12-112.10）与 77.9（65.12-98.64）ng/mL； =.002。诊断为 MS 的男性总睾酮水平较低：5.75（4.00-6.57）与 6.40（5.50-8.40）ng/mL； =.0014 和 SHBG：46.58（35.13-66.28）与 71.97（56.1-92.7）nM/L； < 0.000001。与健康男性相比，MS 男性的 LGSI 指数升高[白细胞介素 18（IL-18）：530.64（409.12-640.56）与 418.85（348.14-496.44）pg/mL； =.000033 和高敏 C 反应蛋白（hs-CRP）：2.15（0.97-4.26）与 1.01（0.41-2.68）ng/mL； =.0057）]。在多变量回归分析中，评估 MS 风险的最高阴性预测值是血清 SHBG 浓度，而最高的阳性预测值是：IL-18、高三酰甘油血症和腰围。在表现为高三酰甘油血症腰围表型的男性中，SHBG 水平降低，同时 IL-18 浓度升高，显著增加了 MS 的风险。
