Department of Neuroscience, Genentech, Inc., South San Francisco, CA 94080, USA.
Department of Neuroscience, Genentech, Inc., South San Francisco, CA 94080, USA.
Neuron. 2019 Nov 6;104(3):429-430. doi: 10.1016/j.neuron.2019.10.021.
Accumulation of abnormal Tau is a characteristic feature of a number of neurodegenerative disorders, called tauopathies. What is the reason for Tau toxicity in neuronal cells? In this issue of Neuron, Sohn et al. (2019) found that FTD mutant Tau-V337M blocks axon initial segment (AIS) plasticity, causing neuronal hyperexcitability.
异常 Tau 的积累是许多神经退行性疾病（称为 Tau 病）的特征。Tau 毒性在神经元细胞中的原因是什么？在本期《神经元》杂志中，Sohn 等人（2019 年）发现 FTD 突变型 Tau-V337M 阻断轴突起始段（AIS）的可塑性，导致神经元过度兴奋。
