正念训练对中国女性孕期压力及下丘脑-垂体-肾上腺轴的影响：一项多中心随机对照试验
Effectiveness of mindfulness training on pregnancy stress and the hypothalamic-pituitary-adrenal axis in women in China: A multicenter randomized controlled trial.
作者信息
Wang Shulei, Zhang Chen, Sun Mengyun, Zhang Daming, Luo Ying, Liang Kairu, Xu Tao, Pan XiaoPing, Zheng Ruimin, Shangguan Fangfang, Wang Jia
机构信息
National Center for Women and Children's Health, China CDC, Beijing, China.
Yantai Center for Disease Control and Prevention, Yantai, Shandong, China.
出版信息
Front Psychol. 2023 Mar 2;14:1073494. doi: 10.3389/fpsyg.2023.1073494. eCollection 2023.
INTRODUCTION
In the past two decades, mindfulness-based intervention programs have gradually become popular.Many studies have confirmed that these programs can effectively alleviate prenatal stress and negative emotion.The mindfulness-based stress-buffering hypothesis suggests that mindfulness training can induce changes in the levels of the cortisol secreted by the HPA axis, thereby reducing stress susceptibility. However, to date, only a few high-quality evidence-based medical studies have analyzed the effect of the mindfulness-based intervention in a maternal population.Thus, this study investigated the effects of a mindfulness-based psychosomatic intervention on pregnancy stress and the HYPERLINK "javascript:;" hypothalamic-pituitary-adrenal (HPA) axis of pregnant Chinese women.
METHODS
Women experiencing first-time pregnancy (n = 117) were randomly allocated to the intervention group or parallel active control group, and data were collected at baseline and post-intervention periods. The participants completed questionnaires regarding mindfulness and pregnancy stress. Saliva samples was collected at the time of waking up, and 30, 45, and 60 min after waking up for analyzing the salivary cortisol levels. We analyzed differences between the two groups and changes within the same group before and after the intervention.
RESULTS AND DISCUSSION
A total of 95 participants completed the trial. Compared with the parallel active control group, the intervention group exhibited lower levels of stress after the intervention (P = 0.047). For HPA-axis-related indicators after the intervention, Delta value (P = 0.01) and AUCM value (P = 0.031) of the intervention group were significantly higher than that of the control group. Mindfulness-based interventions effectively reduced the level of pregnancy stress and adjusted the HPA axis function in pregnant women in China.
CLINICAL TRIAL REGISTRATION
https://www.chictr.org.cn, identifier ChiCTR 2000033149.
引言
在过去二十年中，基于正念的干预项目逐渐流行起来。许多研究证实，这些项目能有效缓解产前压力和负面情绪。基于正念的压力缓冲假说表明，正念训练可引起下丘脑 - 垂体 - 肾上腺（HPA）轴分泌的皮质醇水平变化，从而降低压力易感性。然而，迄今为止，仅有少数高质量的循证医学研究分析了基于正念的干预对孕产妇群体的影响。因此，本研究调查了基于正念的身心干预对中国孕妇的妊娠压力及下丘脑 - 垂体 - 肾上腺（HPA）轴的影响。
方法
首次怀孕的女性（n = 117）被随机分配到干预组或平行的积极对照组，并在基线期和干预后期收集数据。参与者完成关于正念和妊娠压力的问卷。在醒来时以及醒来后30、45和60分钟收集唾液样本，用于分析唾液皮质醇水平。我们分析了两组之间的差异以及干预前后同一组内的变化。
结果与讨论
共有95名参与者完成了试验。与平行的积极对照组相比，干预组在干预后压力水平较低（P = 0.047）。对于干预后的HPA轴相关指标，干预组的Delta值（P = 0.01）和AUCM值（P = 0.031）显著高于对照组。基于正念的干预有效降低了中国孕妇的妊娠压力水平，并调节了HPA轴功能。
临床试验注册
https://www.chictr.org.cn，标识符ChiCTR 2000033149。
Zotero 插件