Center for Human Growth and Development, University of Michigan, Ann Arbor, MI, USA; Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Department of Pediatrics, Peking University First Hospital, Beijing, China.
Appetite. 2020 Mar 1;146:104508. doi: 10.1016/j.appet.2019.104508. Epub 2019 Nov 4.
Intraoral sucrose has analgesic effects in the newborn period. The hedonic and analgesic effects of sucrose overlap and hedonic response to sweet food is associated with adiposity. The potential association between the analgesic effects of intraoral sucrose in the newborn period and subsequent weight gain has not been examined. Healthy, term newborns received 25% intraoral sucrose or water prior to metabolic screen heel stick. Negative affect, quiet alert behavior, and sleepiness were coded during heel stick. Weight and length were measured and z-score (WLZ) calculated at birth, 9, and 18 months. Mixed models tested associations of behavioral response to heel stick with WLZ trajectory among infants receiving sucrose (n = 154) versus water (n = 117). Among infants receiving sucrose prior to heel stick with birth WLZ ≥ the median, less negative affect and more sleepiness during heel stick were each associated with greater increases in WLZ. These associations were not present among infants receiving water only prior to heel stick. Greater analgesic effects of sucrose in the neonate were associated with greater future increases in WLZ, especially among infants with higher birth WLZ. Greater opioid-mediated newborn behavioral response to intraoral sucrose may be a marker for future obesity risk. CLINICAL TRIALS NUMBER: NCT02728141.
口腔内蔗糖在新生儿期具有镇痛作用。蔗糖的愉悦和镇痛作用重叠，对甜食的愉悦反应与肥胖有关。口腔内蔗糖在新生儿期的镇痛作用与随后的体重增加之间的潜在关联尚未被研究。健康的足月新生儿在接受代谢筛查足跟采血前接受 25%的口腔内蔗糖或水。足跟采血期间对负性情绪、安静警觉行为和困倦进行编码。在出生时、9 个月和 18 个月测量体重和长度，并计算体重指数（WLZ）。混合模型测试了足跟采血前接受蔗糖（n=154）与仅接受水（n=117）的婴儿的足跟采血行为反应与 WLZ 轨迹之间的关联。在足跟采血前接受 WLZ≥中位数的蔗糖的婴儿中，足跟采血期间的负性情绪减少和困倦增加与 WLZ 的更大增加相关。在仅接受水的婴儿中，没有这些关联。新生儿对口腔内蔗糖的镇痛作用越强，未来 WLZ 的增加就越大，尤其是在出生 WLZ 较高的婴儿中。口腔内蔗糖对新生儿阿片类药物介导的行为反应增加可能是未来肥胖风险的标志物。临床试验编号：NCT02728141。
