Ramenghi L A, Wood C M, Griffith G C, Levene M I
Division of Paediatrics and Child Health, University of Leeds School of Medicine.
Arch Dis Child Fetal Neonatal Ed. 1996 Mar;74(2):F126-8. doi: 10.1136/fn.74.2.f126.
The potential of sucrose to reduce the pain response in a group of healthy premature infants was investigated. Fifteen infants of 32-34 weeks postmenstrual age were tested in a blind crossover manner on two separate occasions no more than two days apart. Either 1 ml of 25% sucrose solution or sterile water was syringed into the baby's mouth 2 minutes before routine heel lancing. Response to the painful stimuli was measured by duration of cry and by facial expression (pain score). There was a significant reduction in the duration of first cry, the percentage of time spent crying in the 5 minutes after heel prick, and the pain score in the sucrose treated group. It is concluded that sucrose has analgesic effects in healthy premature infants.
研究了蔗糖减轻一组健康早产儿疼痛反应的潜力。对15名孕龄32 - 34周的婴儿进行了两次不超过两天间隔的盲交叉试验。在常规足跟采血前2分钟，将1毫升25%的蔗糖溶液或无菌水用注射器注入婴儿口中。通过哭声持续时间和面部表情（疼痛评分）来测量对疼痛刺激的反应。蔗糖治疗组的首次哭声持续时间、足跟采血后5分钟内啼哭时间百分比和疼痛评分均有显著降低。得出结论，蔗糖对健康早产儿有镇痛作用。
