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从尼泊尔泥蜂巢穴中分离出的产布拉特霉素的链霉菌属菌株C10的基因组序列草图

Draft Genome Sequence of sp. Strain C10, a Producer of Brartemicin, Isolated from a Mud Dauber Wasp Nest in Nepal.

作者信息

Aryal Niraj, Aziz Saefuddin, Rajbhandari Prajwal, Gross Harald

机构信息

Department of Pharmaceutical Biology, Pharmaceutical Institute, University of Tübingen, Tübingen, Germany.

Microbiology Department, Biology Faculty, Jenderal Soedirman University, Purwokerto, Indonesia.

出版信息

Microbiol Resour Announc. 2019 Nov 7;8(45):e01109-19. doi: 10.1128/MRA.01109-19.

DOI:10.1128/MRA.01109-19
PMID:31699765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6838623/
Abstract

sp. strain C10 produces the cytotoxic natural product brartemicin. Here, we report its draft genome sequence to get insight into brartemicin biosynthesis and to enable genome mining for novel secondary metabolites.

摘要

菌株C10产生细胞毒性天然产物布拉特霉素。在此,我们报告其基因组草图序列,以深入了解布拉特霉素的生物合成,并为新型次级代谢产物的基因组挖掘提供便利。

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本文引用的文献

1
antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline.antiSMASH 5.0:二次代谢产物基因组挖掘管道的更新。
Nucleic Acids Res. 2019 Jul 2;47(W1):W81-W87. doi: 10.1093/nar/gkz310.
2
Lipidated Brartemicin Analogues Are Potent Th1-Stimulating Vaccine Adjuvants.脂质体布他霉素类似物是有效的 Th1 刺激疫苗佐剂。
J Med Chem. 2018 Feb 8;61(3):1045-1060. doi: 10.1021/acs.jmedchem.7b01468. Epub 2018 Jan 18.
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sp. ATCC 55076 harbours the largest actinomycete chromosome to date and the kistamicin biosynthetic gene cluster.菌株ATCC 55076拥有迄今为止最大的放线菌染色体以及奇霉素生物合成基因簇。
Medchemcomm. 2017 Apr 1;8(4):780-788. doi: 10.1039/c6md00637j. Epub 2017 Jan 30.
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The complete 12 Mb genome and transcriptome of Nonomuraea gerenzanensis with new insights into its duplicated "magic" RNA polymerase.热河野野村菌的完整12兆碱基基因组和转录组,及其重复的“神奇”RNA聚合酶的新见解
Sci Rep. 2016 Dec 21;6(1):18. doi: 10.1038/s41598-016-0025-0.
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Therapeutic arthropods and other, largely terrestrial, folk-medicinally important invertebrates: a comparative survey and review.治疗性节肢动物及其他主要生活在陆地上、具有重要民间药用价值的无脊椎动物:一项比较性调查与综述
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6
Binding Sites for Acylated Trehalose Analogs of Glycolipid Ligands on an Extended Carbohydrate Recognition Domain of the Macrophage Receptor Mincle.巨噬细胞受体Mincle扩展碳水化合物识别结构域上糖脂配体的酰化海藻糖类似物的结合位点
J Biol Chem. 2016 Sep 30;291(40):21222-21233. doi: 10.1074/jbc.M116.749515. Epub 2016 Aug 19.
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NCBI prokaryotic genome annotation pipeline.美国国立生物技术信息中心原核生物基因组注释管道
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8
Draft Genome Sequence of Nonomuraea sp. TP-A0861, a Producer of Myxochelin A.嗜盐碱诺卡氏菌属菌株TP-A0861(黏铁载体A的产生菌)的基因组序列草图
Genome Announc. 2015 Dec 10;3(6):e01430-15. doi: 10.1128/genomeA.01430-15.
9
The natural product brartemicin is a high affinity ligand for the carbohydrate-recognition domain of the macrophage receptor mincle.天然产物布拉特霉素是巨噬细胞受体小清蛋白碳水化合物识别结构域的高亲和力配体。
Medchemcomm. 2015 Apr 10;6(4):647-652. doi: 10.1039/c4md00512k. Epub 2015 Jan 7.
10
Synthesis and structure-activity relationships studies of brartemicin analogs as anti-invasive agents.布雷替菌素类似物作为抗侵袭剂的合成及构效关系研究。
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