Biotechnology Research Center, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.
J Nat Prod. 2009 May 22;72(5):980-2. doi: 10.1021/np9000575.
Brartemicin (1), a new trehalose-derived metabolite, was isolated from the culture broth of the actinomycete of the genus Nonomuraea. Its structure and absolute configuration were determined by spectroscopic analyses. The new compound inhibited the invasion of murine colon carcinoma 26-L5 cells with an IC(50) value of 0.39 microM in a concentration-dependent manner without showing cytotoxic effects.
布瑞替霉素（1）是一种新型海藻糖衍生代谢产物，从诺卡氏菌属放线菌的发酵液中分离得到。通过光谱分析确定了其结构和绝对构型。该新化合物呈浓度依赖性抑制小鼠结肠癌细胞 26-L5 的侵袭，其 IC50 值为 0.39μM，且无细胞毒性作用。
