Borrelli R, Contaldo F, Reed L A, Isernia C, Di Biase G, Mancini M
Istituto di Medicina Interna e Malattie Dismetaboliche, Università degli Studi di Napoli, Italia.
Int J Vitam Nutr Res. 1988;58(2):236-40.
Aim of this study was to evaluate whether the age of onset of obesity might affect the prevalence of CV risk factors in severely obese patients. Five hundred forty-five (385 F aged 42.3 +/- 7.1 yrs, BMI 47.3 +/- 5.1 w/h2 and 160 M of 39.0 +/- 1.1 yrs and BMI of 41.8 +/- 5.3 w/h2) severely obese patients hospitalized in the Metabolic Unit between 1972 and 1985 were subdivided in four classes according to the age of onset of obesity. Severely obese women with maturity onset obesity (i.e. onset greater than or equal to 20 yrs) (MOO) had higher (p less than or equal to .01) serum glucose (118 vs 103 mg/dl) and triglyceride (167 vs 126 mg/dl) than those with early onset obesity (EOO) (i.e. onset less than or equal to 3 yrs) with the same age, BMI and smoking habits. Similar trend was also found in men. In males arterial blood pressure was found to be higher (p less than or equal to .01) in EOO than in MOO (SBP = 152 vs 133 mmHg and DBP = 92 vs 83 mmHg). Similar trend was found in females. In conclusion age of onset of obesity may, at least in part, affect the prevalence of cardiovascular risk factors in severe obesity.
本研究的目的是评估肥胖发病年龄是否会影响重度肥胖患者心血管危险因素的患病率。1972年至1985年间在代谢科住院的545例重度肥胖患者（385例女性，年龄42.3±7.1岁，体重指数47.3±5.1kg/m²；160例男性，年龄39.0±1.1岁，体重指数41.8±5.3kg/m²）根据肥胖发病年龄分为四类。成熟型肥胖（即发病年龄大于或等于20岁）的重度肥胖女性，与年龄、体重指数和吸烟习惯相同的早发型肥胖（即发病年龄小于或等于3岁）女性相比，血清葡萄糖（118 vs 103mg/dl）和甘油三酯（167 vs 126mg/dl）水平更高（p≤0.01）。男性中也发现了类似趋势。早发型肥胖男性的动脉血压高于成熟型肥胖男性（p≤0.01）（收缩压=152 vs 133mmHg，舒张压=92 vs 83mmHg）。女性中也发现了类似趋势。总之，肥胖发病年龄可能至少在一定程度上影响重度肥胖患者心血管危险因素的患病率。
