Harnish P P, Samuel K
Department of Radiology, University of Rochester Medical Center, New York 14642.
Invest Radiol. 1988 Jul;23(7):534-6. doi: 10.1097/00004424-198807000-00010.
The effect of the radiographic contrast agent diatrizoate on cerebrospinal fluid (CSF) production was determined by ventriculocisternal perfusion. The lateral ventricle and cisterna magna of anesthetized rats and rabbits were cannulated stereotactically and perfused continuously with a H-3 inulin-labeled artificial CSF solution. Baseline collections of CSF began after steady state outflow was established; then, diatrizoate was administered intravenously for 1 hour. The baseline rate of CSF production was compared with that measured during and after the diatrizoate infusion. The baseline CSF production rate was 3.7 +/- 0.1 and 18.6 +/- 1.4 microL/minute in the rat and rabbit, respectively. Diatrizoate decreased the CSF production rate to 2.9 +/- 0.1 and 13.9 +/- 0.9 microL/minute. This reduced rate continued for at least 90 minutes after the end of the diatrizoate infusion, averaging 3.0 +/- 0.1 and 12.0 +/- 0.6 microL/minute in the rat and rabbit, respectively. These results confirm that decreased CSF production induced by the intravenous administration of diatrizoate is not species specific and is observed with the ventriculocisternal perfusion method of measuring CSF production rates.
通过脑室脑池灌注法测定了放射造影剂泛影葡胺对脑脊液（CSF）生成的影响。对麻醉后的大鼠和兔子进行立体定向插管，分别将其侧脑室和枕大池与用H-3菊粉标记的人工脑脊液溶液进行连续灌注。在建立稳定的流出状态后开始收集脑脊液基线样本；然后，静脉注射泛影葡胺1小时。将脑脊液生成的基线速率与泛影葡胺输注期间及输注后的测量值进行比较。大鼠和兔子的脑脊液生成基线速率分别为3.7±0.1和18.6±1.4微升/分钟。泛影葡胺使脑脊液生成速率降至2.9±0.1和13.9±0.9微升/分钟。在泛影葡胺输注结束后，这种降低的速率至少持续90分钟，大鼠和兔子的平均速率分别为3.0±0.1和12.0±0.6微升/分钟。这些结果证实，静脉注射泛影葡胺引起的脑脊液生成减少并非物种特异性的，并且在用脑室脑池灌注法测量脑脊液生成速率时可以观察到。
