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撑开催化位点。

Wedging open a catalytic site.

机构信息

Department of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers, the State University of New Jersey, Newark, United States.

出版信息

Elife. 2019 Nov 8;8:e52418. doi: 10.7554/eLife.52418.

DOI:10.7554/eLife.52418
PMID:31701871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6839915/
Abstract

The activation mechanism of the nitric oxide receptor has been revealed by cryo-electron microscopy.

摘要

低温电子显微镜揭示了一氧化氮受体的激活机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6d3/6839915/781f5fd6b1c5/elife-52418-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6d3/6839915/781f5fd6b1c5/elife-52418-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6d3/6839915/781f5fd6b1c5/elife-52418-fig1.jpg

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2
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Discovery and development of next generation sGC stimulators with diverse multidimensional pharmacology and broad therapeutic potential.
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GAPDH delivers heme to soluble guanylyl cyclase.GAPDH 将血红素递送给可溶性鸟苷酸环化酶。
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发现和开发具有多维药理学和广泛治疗潜力的新一代可溶性鸟苷酸环化酶刺激剂。
Nitric Oxide. 2018 Aug 1;78:72-80. doi: 10.1016/j.niox.2018.05.009. Epub 2018 May 31.
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