可溶性鸟苷酸环化酶的生理激活和失活。
Physiological activation and deactivation of soluble guanylate cyclase.
机构信息
Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA; California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA, USA.
出版信息
Nitric Oxide. 2018 Jul 1;77:65-74. doi: 10.1016/j.niox.2018.04.011. Epub 2018 Apr 25.
Abstract
Soluble guanylate cyclase (sGC) is responsible for transducing the gaseous signaling molecule nitric oxide (NO) into the ubiquitous secondary signaling messenger cyclic guanosine monophosphate in eukaryotic organisms. sGC is exquisitely tuned to respond to low levels of NO, allowing cells to respond to non-toxic levels of NO. In this review, the structure of sGC is discussed in the context of sGC activation and deactivation. The sequence of events in the activation pathway are described into a comprehensive model of in vivo sGC activation as elucidated both from studies with purified enzyme and those done in cells. This model is then used to discuss the deactivation of sGC, as well as the molecular mechanisms of pathophysiological deactivation.
摘要
可溶性鸟苷酸环化酶（sGC）负责将气态信号分子一氧化氮（NO）转导为真核生物中无处不在的二级信号信使环鸟苷酸单磷酸。sGC 对低水平的 NO 具有高度的敏感性，使细胞能够对非毒性水平的 NO 做出反应。在这篇综述中，sGC 的结构是在 sGC 的激活和失活的背景下讨论的。激活途径中的事件顺序被描述为一个综合的体内 sGC 激活模型，该模型是通过纯化酶的研究和细胞内的研究来阐明的。然后，该模型被用于讨论 sGC 的失活，以及病理生理学失活的分子机制。
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