Shanghai Tenth People's Hospital, Tongji Hospital, School of Medicine, School of Materials Science and Engineering, Tongji University, Shanghai 201804, P. R. China.
Biomater Sci. 2019 Dec 17;8(1):313-324. doi: 10.1039/c9bm01207a.
Unhealable diabetic wounds and disabling scar formation in severe wounds need to be addressed with the help of multiple techniques. Here we put forward an idea to use exosomes loaded into a supporting scaffold to rebuild the vascular transportation system, which could solve hypoxia and infertility in these wounds. A highly efficient self-healing and biocompatible natural-based methylcellulose-chitosan hydrogel loaded with biological exosome nanoparticles has the appropriate strength and is made by an easy preparation process, and it eventually achieves the integrated structure needed for healing severe diabetic conditions. Hydrogels perform well in the cell proliferation and skin remodeling stages because of their three-dimensional porous structure, and self-healing and adhesion properties. Also, exosomes accumulated to an effective concentration for a period of time could induce proliferation, especially relating to vascular formation. After the overpass (vascular) has been constructed with the help of the base (hydrogel) and workers (exosomes), the society (skin) is reconstructed under a system of supply and regulation. The research results indicate that these novel complex hydrogels loaded with exosomes provide wide prospects for the healing of severe wounds.
未愈合的糖尿病伤口和严重伤口中的致残性瘢痕形成需要多种技术的帮助来解决。在这里，我们提出了一个想法，即使用负载在支撑支架中的细胞外体来重建血管运输系统，这可以解决这些伤口中的缺氧和不孕问题。一种高效的自修复和生物相容的天然甲基纤维素-壳聚糖水凝胶，负载有生物细胞外体纳米颗粒，具有适当的强度，并且通过简单的制备过程制成，最终实现了治愈严重糖尿病所需的整体结构。水凝胶由于其三维多孔结构、自修复和粘附特性，在细胞增殖和皮肤重塑阶段表现良好。此外，细胞外体在一段时间内积累到有效浓度可诱导增殖，特别是与血管形成有关。在基础（水凝胶）和工人（细胞外体）的帮助下构建了天桥（血管）之后，在供应和调节系统的作用下重建了社会（皮肤）。研究结果表明，这些负载细胞外体的新型复杂水凝胶为严重伤口的愈合提供了广阔的前景。
