Department of Biochemistry, Karpagam Academy of Higher Education, Eachanari, Coimbatore 641021, Tamil Nadu, India.
Department of Life Sciences, School of Life Sciences, Central University of Tamil Nadu, Thiruvarur 610005, India.
Curr Protein Pept Sci. 2020;21(1):52-65. doi: 10.2174/1389203720666191106113435.
Hormones are known to influence various body systems that include skeletal, cardiac, digestive, excretory, and immune systems. Emerging investigations suggest the key role played by secretions of endocrine glands in immune cell differentiation, proliferation, activation, and memory attributes of the immune system. The link between steroid hormones such as glucocorticoids and inflammation is widely known. However, the role of peptide hormones and amino acid derivatives such as growth and thyroid hormones, prolactin, dopamine, and thymopoietin in regulating the functioning of the immune system remains unclear. Here, we reviewed the findings pertinent to the functional role of hormone-immune interactions in health and disease and proposed perspective directions for translational research in the field.
激素被认为会影响包括骨骼、心脏、消化、排泄和免疫系统在内的各种身体系统。新出现的研究表明，内分泌腺分泌在免疫细胞分化、增殖、激活和免疫系统的记忆属性中起着关键作用。人们广泛了解类固醇激素（如糖皮质激素）与炎症之间的联系。然而，生长和甲状腺激素、催乳素、多巴胺和胸腺生成素等肽激素和氨基酸衍生物在调节免疫系统功能方面的作用尚不清楚。在这里，我们回顾了与激素-免疫相互作用在健康和疾病中的功能作用相关的发现，并为该领域的转化研究提出了展望方向。
