Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.
Collaborative Innovation Center of Henan Province for Cancer Chemoprevention, Zhengzhou, Henan 450001, China.
Anticancer Agents Med Chem. 2020;20(3):276-285. doi: 10.2174/1871520619666191105125409.
Cancer is increasingly becoming the leading cause of death in many countries, and malignant tumours of the digestive system account for majority of cancer incidence and mortality cases. Metabolism has been identified as a core hallmark of cancer. Peroxisome proliferator activated receptor gamma coactivator-1 alpha (PGC-1α) is a pivotal regulator of mitochondrial energy metabolism. Accumulating evidence reveals that PGC-1α is essential in cancer development.
We summarize the latest research progress of PGC-1α in common digestive system malignant tumours. Some related modulators and pathways are analyzed as well.
We conducted a literature review on the development of PGC-1α in common digestive system malignant tumours.
In colorectal cancer, PGC-1α appears to provide growth advantages by different pathways, although it has also been reported to have opposite effects. The previous studies of PGC-1α on liver cancer also demonstrated different effects by sundry pathways. Concerning gastric cancer, PGC-1α promotes cell proliferation, apoptosis in vitro and tumour growth in vivo. AMPK/SIRT1/PGC-1α is related to the inhibition of apoptosis in pancreatic cancer cells. Pancreatic cancer stem cells are strongly dependent on mitochondrial oxidative phosphorylation. PGC-1α is required to maintain the stemness property of pancreatic cancer stem cells.
We explore diverse mechanisms that explain the dichotomous functions of PGC-1α on tumorigenesis, and discuss the latest research concerning digestive system malignant tumours. This review would provide better comprehension of the field and a basis for further studies associated with PGC-1α in digestive system cancers.
癌症在许多国家日益成为主要死因，消化系统恶性肿瘤占癌症发病率和死亡率的大多数。代谢已被确定为癌症的核心标志之一。过氧化物酶体增殖物激活受体γ共激活因子-1α（PGC-1α）是线粒体能量代谢的关键调节因子。越来越多的证据表明 PGC-1α 在癌症发展中至关重要。
我们总结了 PGC-1α 在常见消化系统恶性肿瘤中的最新研究进展，并分析了一些相关的调节剂和途径。
我们对 PGC-1α 在常见消化系统恶性肿瘤中的发展进行了文献综述。
在结直肠癌中，PGC-1α 通过不同途径似乎提供了生长优势，尽管也有报道称其具有相反的作用。之前关于 PGC-1α 在肝癌中的研究也通过各种途径证明了不同的作用。关于胃癌，PGC-1α 促进细胞增殖、体外凋亡和体内肿瘤生长。AMPK/SIRT1/PGC-1α 与胰腺癌细胞凋亡抑制有关。胰腺癌细胞依赖于线粒体氧化磷酸化。PGC-1α 是维持胰腺癌细胞干性所必需的。
我们探讨了多种机制来解释 PGC-1α 在肿瘤发生中的双重作用，并讨论了与消化系统恶性肿瘤相关的最新研究。这篇综述将为该领域提供更好的理解，并为与消化系统癌症中 PGC-1α 相关的进一步研究提供基础。
