García-Costela María, Escudero-Feliú Julia, Puentes-Pardo Jose D, San Juán Sara Moreno, Morales-Santana Sonia, Ríos-Arrabal Sandra, Carazo Ángel, León Josefa
Research Unit, Biosanitary Research Institute of Granada, ibs.GRANADA, Granada, Spain.
Cytometry and Michroscopy Research Service, Biosanitary Research Institute of Granada, ibs.GRANADA, Granada, Spain.
Front Endocrinol (Lausanne). 2020 Sep 11;11:638. doi: 10.3389/fendo.2020.00638. eCollection 2020.
Pancreatic cancer is one of the most lethal cancers worldwide due to its symptoms, early metastasis, and chemoresistance. Thus, the mechanisms contributing to pancreatic cancer progression require further exploration. Circadian rhythms are the daily oscillations of multiple biological processes regulated by an endogenous clock. Several evidences suggest that the circadian clock may play an important role in the cell cycle, cell proliferation and apoptosis. In addition, timing of chemotherapy or radiation treatment can influence the efficacy and toxicity treatment. Here, we revisit the studies on circadian clock as an emerging target for therapy in pancreatic cancer. We highlight those potential circadian genes regulators that are commonly affected in pancreatic cancer according to most recent reports.
胰腺癌是全球最致命的癌症之一，因其症状、早期转移和化疗耐药性。因此，导致胰腺癌进展的机制需要进一步探索。昼夜节律是由内源性生物钟调节的多种生物过程的每日振荡。有证据表明，生物钟可能在细胞周期、细胞增殖和凋亡中发挥重要作用。此外，化疗或放疗的时间会影响治疗效果和毒性。在此，我们重新审视关于生物钟作为胰腺癌新兴治疗靶点的研究。我们根据最新报道强调那些在胰腺癌中普遍受影响的潜在生物钟基因调节因子。
