Center for Dermatoepidemiology-111D, Veterans Affairs Medical Center, Providence, Rhode Island.
Department of Dermatology, Alpert Medical School of Brown University, Providence, Rhode Island.
Dermatol Surg. 2020 Sep;46(9):1135-1140. doi: 10.1097/DSS.0000000000002261.
Keratinocyte carcinoma (KC) mortality is relatively modest and its measures are subject to considerable error. Deaths due to KC have been decreasing through 2000 and were relatively stable until 2010.
To estimate the KC mortality rates (MRs) from 2011 to 2017 in USA based on death certificates.
A population-based analysis of Center of Disease Control and Prevention data. Main outcomes and measures were the age-adjusted (US 2000 standard population) MRs.
Overall, KC MRs increased significantly (b = 0.04, p < .01). For the period studied, KC MR was 1.24 per 100,000 persons per year (0.62 for sun-exposed sites, 0.38 for genital and 0.23 for perianal sites). At sun-exposed genital and perianal anatomic sites, KC MRs have been increasing in whites, but not in blacks.
There was a 17% decrease in the KC MRs until 2000, followed by an increase of 44% through 2017. The accuracy of KC MRs is uncertain. If indeed the increase in mortality is verified, causes may include an increase in KC incidence, an increase of immunosuppressed populations, and changes in the cause of death documentation.
角化细胞癌（KC）的死亡率相对较低，其死亡率的测量存在很大误差。截至 2000 年，因 KC 导致的死亡率一直在下降，并且在 2010 年之前相对稳定。
根据死亡证明，估计 2011 年至 2017 年美国 KC 的死亡率（MR）。
采用基于人群的疾病控制和预防中心数据分析。主要结局和测量指标为年龄调整（2000 年美国标准人群）的 MR。
总体而言，KC 的 MR 显著增加（b = 0.04，p <.01）。在所研究的期间，KC 的 MR 为每年每 10 万人 1.24 人（暴露于阳光的部位为 0.62，生殖器部位为 0.38，肛门周围部位为 0.23）。在暴露于阳光的生殖器和肛门周围解剖部位，白人 KC 的 MR 一直在增加，但黑人没有增加。
2000 年之前，KC 的 MR 下降了 17%，之后到 2017 年增加了 44%。KC 的 MR 准确性不确定。如果死亡率确实增加，原因可能包括 KC 发病率增加、免疫抑制人群增加以及死亡原因记录的变化。
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